Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation

Gerard L Brien; Adrian P Bracken

doi:10.1016/j.semcdb.2009.07.010

Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation

Gerard L Brien, Adrian P Bracken

School of Population Health Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

Mammalian development is a highly complex and tightly regulated process. Transcription factors and chromatin remodelers, acting downstream of cell signalling pathways, are the key intrinsic factors which control gene expression. Recent advances in transcriptomics are allowing biologists to begin to unravel the complex biological roles played by these factors. This review focuses on how genome-wide gene expression and chromatin immunoprecipitation studies are expanding our understanding of the roles played by transcription factors and chromatin remodelers during cell fate decisions in development and differentiation.

Original language	English
Pages (from-to)	835-41
Number of pages	7
Journal	Seminars in Cell and Developmental Biology
Volume	20
Issue number	7
DOIs	https://doi.org/10.1016/j.semcdb.2009.07.010
Publication status	Published - Sept 2009

Keywords / Materials (for Non-textual outputs)

Animals
Cell Differentiation
Chromatin Assembly and Disassembly
Chromatin Immunoprecipitation
Gene Expression Profiling/methods
Gene Expression Regulation, Developmental
Humans
Transcription Factors/genetics

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10.1016/j.semcdb.2009.07.010

Cite this

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title = "Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation",

abstract = "Mammalian development is a highly complex and tightly regulated process. Transcription factors and chromatin remodelers, acting downstream of cell signalling pathways, are the key intrinsic factors which control gene expression. Recent advances in transcriptomics are allowing biologists to begin to unravel the complex biological roles played by these factors. This review focuses on how genome-wide gene expression and chromatin immunoprecipitation studies are expanding our understanding of the roles played by transcription factors and chromatin remodelers during cell fate decisions in development and differentiation.",

keywords = "Animals, Cell Differentiation, Chromatin Assembly and Disassembly, Chromatin Immunoprecipitation, Gene Expression Profiling/methods, Gene Expression Regulation, Developmental, Humans, Transcription Factors/genetics",

author = "Brien, \{Gerard L\} and Bracken, \{Adrian P\}",

year = "2009",

month = sep,

doi = "10.1016/j.semcdb.2009.07.010",

language = "English",

volume = "20",

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journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

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}

TY - JOUR

T1 - Transcriptomics

T2 - unravelling the biology of transcription factors and chromatin remodelers during development and differentiation

AU - Brien, Gerard L

AU - Bracken, Adrian P

PY - 2009/9

Y1 - 2009/9

N2 - Mammalian development is a highly complex and tightly regulated process. Transcription factors and chromatin remodelers, acting downstream of cell signalling pathways, are the key intrinsic factors which control gene expression. Recent advances in transcriptomics are allowing biologists to begin to unravel the complex biological roles played by these factors. This review focuses on how genome-wide gene expression and chromatin immunoprecipitation studies are expanding our understanding of the roles played by transcription factors and chromatin remodelers during cell fate decisions in development and differentiation.

AB - Mammalian development is a highly complex and tightly regulated process. Transcription factors and chromatin remodelers, acting downstream of cell signalling pathways, are the key intrinsic factors which control gene expression. Recent advances in transcriptomics are allowing biologists to begin to unravel the complex biological roles played by these factors. This review focuses on how genome-wide gene expression and chromatin immunoprecipitation studies are expanding our understanding of the roles played by transcription factors and chromatin remodelers during cell fate decisions in development and differentiation.

KW - Animals

KW - Cell Differentiation

KW - Chromatin Assembly and Disassembly

KW - Chromatin Immunoprecipitation

KW - Gene Expression Profiling/methods

KW - Gene Expression Regulation, Developmental

KW - Humans

KW - Transcription Factors/genetics

U2 - 10.1016/j.semcdb.2009.07.010

DO - 10.1016/j.semcdb.2009.07.010

M3 - Review article

C2 - 19682593

SN - 1084-9521

VL - 20

SP - 835

EP - 841

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 7

ER -

Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation

Abstract

Keywords / Materials (for Non-textual outputs)

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