Transgenic sheep designed for transplantation studies

W. A. Ritchie, T. King, Claire Neil, Ailsa Carlisle, Simon Lillico, G. McLachlan, C. B. Whitelaw

Research output: Contribution to journalArticlepeer-review

Abstract

Lentiviral vectors have recently emerged as an efficient method of transgene delivery to the germline of animals. We now demonstrate that combining this efficiency with embryo splitting procedures enables the production of monozygotic twins, one of which is transgenic. We propose that this approach can be used to generate animals in which cell or tissue transplantation can be achieved without the use of immunosuppressive regimes.
Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalMolecular Reproduction and Development
Volume76
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • cell therapies
  • embryology
  • monozygotic
  • ovine
  • transgene

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