Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review

Imeshi Wijetunga, Laura E. Mcveigh, Antonia Charalambous, Agne Antanaviciute, Ian M. Carr, Amit Nair, K. Raj Prasad, Nicola Ingram, P. Louise Coletta

Research output: Contribution to journalArticlepeer-review

Abstract

Cholangiocarcinoma (CCA) is a rare disease with poor outcomes and limited research efforts into novel treatment options. A systematic review of CCA biomarkers was undertaken to identify promising biomarkers that may be used for theranosis (therapy and diagnosis). MEDLINE/EMBASE databases (1996–2019) were systematically searched using two strategies to identify biomarker studies
of CCA. The PANTHER Go-Slim classification system and STRING network version 11.0 were used to interrogate the identified biomarkers. The TArget Selection Criteria for Theranosis (TASC-T) score was used to rank identified proteins as potential targetable biomarkers for theranosis. The following proteins scored the highest, CA9, CLDN18, TNC, MMP9, and EGFR, and they were evaluated in
detail. None of these biomarkers had high sensitivity or specificity for CCA but have potential for theranosis. This review is unique in that it describes the process of selecting suitable markers for theranosis, which is also applicable to other diseases. This has highlighted existing validated markers of CCA that can be used for active tumor targeting for the future development of targeted theranostic delivery systems. It also emphasizes the relevance of bioinformatics in aiding the search for validated biomarkers that could be repurposed for theranosis.
Original languageEnglish
Pages (from-to)2817
JournalCancers
Volume12
Issue number10
Early online date30 Sep 2020
DOIs
Publication statusE-pub ahead of print - 30 Sep 2020

Keywords

  • biomarkers
  • cholangiocarcinoma
  • theranosis
  • therapy and diagnosis
  • biomarker selection

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