Translating curcumin to the clinic for lung cancer prevention: evaluation of the preclinical evidence for its utility in primary, secondary, and tertiary prevention strategies

Lynne M Howells, Jagdish Mahale, Stewart Sale, Laura McVeigh, William P Steward, Anne Thomas, Karen Brown

Research output: Contribution to journalReview articlepeer-review

Abstract

Lung cancer is responsible for over one million deaths worldwide each year. Smoking cessation for lung cancer prevention remains key, but it is increasingly acknowledged that prevention strategies also need to focus on high-risk groups, including ex-smokers, and patients who have undergone resection of a primary tumor. Models for chemoprevention of lung cancer often present conflicting results, making rational design of lung cancer chemoprevention trials challenging. There has been much focus on use of dietary bioactive compounds in lung cancer prevention strategies, primarily due to their favorable toxicity profile and long history of use within the human populace. One such compound is curcumin, derived from the spice turmeric. This review summarizes and stratifies preclinical evidence for chemopreventive efficacy of curcumin in models of lung cancer, and adjudges the weight of evidence for use of curcumin in lung cancer chemoprevention strategies.

Original languageEnglish
Pages (from-to)483-94
Number of pages12
JournalJournal of pharmacology and experimental therapeutics
Volume350
Issue number3
DOIs
Publication statusPublished - Sep 2014

Keywords

  • Acute Lung Injury/drug therapy
  • Animals
  • Cell Line, Tumor
  • Curcumin/administration & dosage
  • Evidence-Based Medicine/methods
  • Humans
  • Lung Neoplasms/drug therapy
  • Primary Prevention/methods
  • Secondary Prevention/methods
  • Smoking Cessation/methods
  • Tertiary Prevention/methods
  • Translational Medical Research/methods

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