Translation-coupled mRNA quality control mechanisms.

Laura Monaghan; Dasa Longman; Javier F. Caceres

doi:10.15252/embj.2023114378

Translation-coupled mRNA quality control mechanisms.

Laura Monaghan, Dasa Longman, Javier F. Caceres^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

mRNA surveillance pathways are essential for accurate gene
expression and to maintain translation homeostasis, ensuring the
production of fully functional proteins. Future insights into mRNA
quality control pathways will enable us to understand how cellular
mRNA levels are controlled, how defective or unwanted mRNAs
can be eliminated, and how dysregulation of these can contribute
to human disease. Here we review translation-coupled mRNA quality control mechanisms, including the non-stop and no-go mRNA
decay pathways, describing their mechanisms, shared trans-acting
factors, and differences. We also describe advances in our understanding of the nonsense-mediated mRNA decay (NMD) pathway,
highlighting recent mechanistic findings, the discovery of novel
factors, as well as the role of NMD in cellular physiology and its
impact on human disease

Original language	English
Journal	EMBO Journal
DOIs	https://doi.org/10.15252/embj.2023114378
Publication status	Published - 22 Aug 2023

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The EMBO Journal - 2023 - MonaghanFinal published version, 1.14 MBLicence: Creative Commons: Attribution (CC-BY)

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title = "Translation-coupled mRNA quality control mechanisms.",

abstract = "mRNA surveillance pathways are essential for accurate geneexpression and to maintain translation homeostasis, ensuring theproduction of fully functional proteins. Future insights into mRNAquality control pathways will enable us to understand how cellularmRNA levels are controlled, how defective or unwanted mRNAscan be eliminated, and how dysregulation of these can contributeto human disease. Here we review translation-coupled mRNA quality control mechanisms, including the non-stop and no-go mRNAdecay pathways, describing their mechanisms, shared trans-actingfactors, and differences. We also describe advances in our understanding of the nonsense-mediated mRNA decay (NMD) pathway,highlighting recent mechanistic findings, the discovery of novelfactors, as well as the role of NMD in cellular physiology and itsimpact on human disease",

author = "Laura Monaghan and Dasa Longman and Caceres, {Javier F.}",

note = "Funding Information: We thank Craig Nicol (MRC IGC core facility) for help with preparation of figures. This work was supported by Core funding to the MRC Human Genetics Unit from the Medical Research Council (JFC). Publisher Copyright: {\textcopyright} 2023 The Authors. Published under the terms of the CC BY 4.0 license.",

year = "2023",

month = aug,

day = "22",

doi = "10.15252/embj.2023114378",

language = "English",

journal = "EMBO Journal",

issn = "0261-4189",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Translation-coupled mRNA quality control mechanisms.

AU - Monaghan, Laura

AU - Longman, Dasa

AU - Caceres, Javier F.

N1 - Funding Information: We thank Craig Nicol (MRC IGC core facility) for help with preparation of figures. This work was supported by Core funding to the MRC Human Genetics Unit from the Medical Research Council (JFC). Publisher Copyright: © 2023 The Authors. Published under the terms of the CC BY 4.0 license.

PY - 2023/8/22

Y1 - 2023/8/22

N2 - mRNA surveillance pathways are essential for accurate geneexpression and to maintain translation homeostasis, ensuring theproduction of fully functional proteins. Future insights into mRNAquality control pathways will enable us to understand how cellularmRNA levels are controlled, how defective or unwanted mRNAscan be eliminated, and how dysregulation of these can contributeto human disease. Here we review translation-coupled mRNA quality control mechanisms, including the non-stop and no-go mRNAdecay pathways, describing their mechanisms, shared trans-actingfactors, and differences. We also describe advances in our understanding of the nonsense-mediated mRNA decay (NMD) pathway,highlighting recent mechanistic findings, the discovery of novelfactors, as well as the role of NMD in cellular physiology and itsimpact on human disease

AB - mRNA surveillance pathways are essential for accurate geneexpression and to maintain translation homeostasis, ensuring theproduction of fully functional proteins. Future insights into mRNAquality control pathways will enable us to understand how cellularmRNA levels are controlled, how defective or unwanted mRNAscan be eliminated, and how dysregulation of these can contributeto human disease. Here we review translation-coupled mRNA quality control mechanisms, including the non-stop and no-go mRNAdecay pathways, describing their mechanisms, shared trans-actingfactors, and differences. We also describe advances in our understanding of the nonsense-mediated mRNA decay (NMD) pathway,highlighting recent mechanistic findings, the discovery of novelfactors, as well as the role of NMD in cellular physiology and itsimpact on human disease

U2 - 10.15252/embj.2023114378

DO - 10.15252/embj.2023114378

M3 - Review article

SN - 0261-4189

JO - EMBO Journal

JF - EMBO Journal

ER -

Translation-coupled mRNA quality control mechanisms.

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