Translational biophysics: the physical sciences in molecular medicine

Maxim G. Ryadnov, Eleonora Cerasoli, Glenn J. Martyna, Jason Crain

Research output: Contribution to journalEditorialpeer-review

Abstract

Traditional approaches of medicinal chemistry focus on finding novel structures possessing desired biological properties, or on relating chemical details to a particular biological function Here the aim is to hit the therapeutic target of interest rather than to understand and exploit its origin Consequently, molecular mechanisms underlying the disease are of much lesser concern, with intuitive designs continuing to be most successful Physical sciences can offer alternative ways of tackling the problem by establishing structural continuums between different time and length scales spanning physical phenomena of life processes and their disorders This can be achieved by the use of approximated physical models providing a rationale for interconversions between different but related scales, which can further be extended with chemical details obtained from complementary experimental data

Original languageEnglish
Pages (from-to)1633-1639
Number of pages7
JournalFuture medicinal chemistry
Volume2
Issue number11
DOIs
Publication statusPublished - Nov 2010

Keywords

  • CELL-PENETRATING PEPTIDES
  • ANTIMICROBIAL PEPTIDES
  • PROTEIN OLIGOMERS
  • MEMBRANE-FUSION
  • MECHANISM
  • GP41
  • DELIVERY
  • DOMAIN
  • HIV-1

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