Translational research will fail without surgical leadership: SCOTRRCC a successful surgeon-led Nationwide translational research infrastructure in renal cancer

Grant D Stewart; Antony C P Riddick; Frances Rae; Craig Marshall; Linda MacLeod; Fiach C O'Mahony; Alexander Laird; Alan McNeill; Kevin M O'Connor; Marie O'Donnell; Paul Fineron; Duncan B McLaren; Michael Aitchison; Grenville Oades; Jane Hair; Morag Seywright; Brian Little; Robert Nairn; Gavin Lamb; Torquil Macleod; Ian Dunn; Alison Ramsey; Roderick Campbell; Steve Leung; Liza McLornan; Maeve Rahilly; Ian Wilson; Anne-Marie Pollock; David J Harrison

doi:10.1016/j.surge.2015.03.001

Translational research will fail without surgical leadership: SCOTRRCC a successful surgeon-led Nationwide translational research infrastructure in renal cancer

Grant D Stewart, Antony C P Riddick, Frances Rae, Craig Marshall, Linda MacLeod, Fiach C O'Mahony, Alexander Laird, Alan McNeill, Kevin M O'Connor, Marie O'Donnell, Paul Fineron, Duncan B McLaren, Michael Aitchison, Grenville Oades, Jane Hair, Morag Seywright, Brian Little, Robert Nairn, Gavin Lamb, Torquil MacleodIan Dunn, Alison Ramsey, Roderick Campbell, Steve Leung, Liza McLornan, Maeve Rahilly, Ian Wilson, Anne-Marie Pollock, David J Harrison

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

BACKGROUND: High quality human biosamples with associated high quality clinical data are essential for successful translational research. Despite this, the traditional approach is for the surgeon to act as a technician in the tissue collection act. Biomarker research presents multiple challenges and the field is littered with failures. Tissue quality, poor clinical information, small sample numbers and lack of validation cohorts are just a few reasons for failure. It is clear that the surgeon involved in tissue acquisition must be fully engaged in the process of biosampling for a specific condition, as this will negate many of the issues for translational research failure due to an inadequate bioresource.

APPROACH: In this Matter for Debate paper, the Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC) is discussed as an example of a urological surgery lead bioresource which has resulted in a National collection of renal cancer tissue and blood (from over 900 patients to date), negating all of the traditional issues with biobanks because of close enagagement and acknowledgement of urologists and uropathologists from seven centres around Scotland. SCOTRRCC has leveraged renal cancer research in Scotland resulting in several high impact publications and providing a springboard for future research in this disease in Scotland and beyond.

CONCLUSIONS: The SCOTRRCC model presented here can be transferred to other surgical disciplines for success in translational research.

Original language	English
Pages (from-to)	181-186
Number of pages	5
Journal	The Surgeon
Volume	13
Issue number	4
Early online date	30 Apr 2015
DOIs	https://doi.org/10.1016/j.surge.2015.03.001
Publication status	Published - Aug 2015

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Stewart, G. D., Riddick, A. C. P., Rae, F., Marshall, C., MacLeod, L., O'Mahony, F. C., Laird, A., McNeill, A., O'Connor, K. M., O'Donnell, M., Fineron, P., McLaren, D. B., Aitchison, M., Oades, G., Hair, J., Seywright, M., Little, B., Nairn, R., Lamb, G., ... Harrison, D. J. (2015). Translational research will fail without surgical leadership: SCOTRRCC a successful surgeon-led Nationwide translational research infrastructure in renal cancer. The Surgeon, 13(4), 181-186. https://doi.org/10.1016/j.surge.2015.03.001

@article{ada73fe6e33142a4a78cb64cd9ee6c21,

title = "Translational research will fail without surgical leadership: SCOTRRCC a successful surgeon-led Nationwide translational research infrastructure in renal cancer",

abstract = "BACKGROUND: High quality human biosamples with associated high quality clinical data are essential for successful translational research. Despite this, the traditional approach is for the surgeon to act as a technician in the tissue collection act. Biomarker research presents multiple challenges and the field is littered with failures. Tissue quality, poor clinical information, small sample numbers and lack of validation cohorts are just a few reasons for failure. It is clear that the surgeon involved in tissue acquisition must be fully engaged in the process of biosampling for a specific condition, as this will negate many of the issues for translational research failure due to an inadequate bioresource.APPROACH: In this Matter for Debate paper, the Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC) is discussed as an example of a urological surgery lead bioresource which has resulted in a National collection of renal cancer tissue and blood (from over 900 patients to date), negating all of the traditional issues with biobanks because of close enagagement and acknowledgement of urologists and uropathologists from seven centres around Scotland. SCOTRRCC has leveraged renal cancer research in Scotland resulting in several high impact publications and providing a springboard for future research in this disease in Scotland and beyond.CONCLUSIONS: The SCOTRRCC model presented here can be transferred to other surgical disciplines for success in translational research.",

author = "Stewart, {Grant D} and Riddick, {Antony C P} and Frances Rae and Craig Marshall and Linda MacLeod and O'Mahony, {Fiach C} and Alexander Laird and Alan McNeill and O'Connor, {Kevin M} and Marie O'Donnell and Paul Fineron and McLaren, {Duncan B} and Michael Aitchison and Grenville Oades and Jane Hair and Morag Seywright and Brian Little and Robert Nairn and Gavin Lamb and Torquil Macleod and Ian Dunn and Alison Ramsey and Roderick Campbell and Steve Leung and Liza McLornan and Maeve Rahilly and Ian Wilson and Anne-Marie Pollock and Harrison, {David J}",

year = "2015",

month = aug,

doi = "10.1016/j.surge.2015.03.001",

language = "English",

volume = "13",

pages = "181--186",

journal = "The Surgeon",

issn = "1479-666X",

publisher = "Elsevier",

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Stewart, GD, Riddick, ACP, Rae, F, Marshall, C, MacLeod, L, O'Mahony, FC, Laird, A, McNeill, A, O'Connor, KM, O'Donnell, M, Fineron, P, McLaren, DB, Aitchison, M, Oades, G, Hair, J, Seywright, M, Little, B, Nairn, R, Lamb, G, Macleod, T, Dunn, I, Ramsey, A, Campbell, R, Leung, S, McLornan, L, Rahilly, M, Wilson, I, Pollock, A-M & Harrison, DJ 2015, 'Translational research will fail without surgical leadership: SCOTRRCC a successful surgeon-led Nationwide translational research infrastructure in renal cancer', The Surgeon, vol. 13, no. 4, pp. 181-186. https://doi.org/10.1016/j.surge.2015.03.001

TY - JOUR

T1 - Translational research will fail without surgical leadership

T2 - SCOTRRCC a successful surgeon-led Nationwide translational research infrastructure in renal cancer

AU - Stewart, Grant D

AU - Riddick, Antony C P

AU - Rae, Frances

AU - Marshall, Craig

AU - MacLeod, Linda

AU - O'Mahony, Fiach C

AU - Laird, Alexander

AU - McNeill, Alan

AU - O'Connor, Kevin M

AU - O'Donnell, Marie

AU - Fineron, Paul

AU - McLaren, Duncan B

AU - Aitchison, Michael

AU - Oades, Grenville

AU - Hair, Jane

AU - Seywright, Morag

AU - Little, Brian

AU - Nairn, Robert

AU - Lamb, Gavin

AU - Macleod, Torquil

AU - Dunn, Ian

AU - Ramsey, Alison

AU - Campbell, Roderick

AU - Leung, Steve

AU - McLornan, Liza

AU - Rahilly, Maeve

AU - Wilson, Ian

AU - Pollock, Anne-Marie

AU - Harrison, David J

PY - 2015/8

Y1 - 2015/8

N2 - BACKGROUND: High quality human biosamples with associated high quality clinical data are essential for successful translational research. Despite this, the traditional approach is for the surgeon to act as a technician in the tissue collection act. Biomarker research presents multiple challenges and the field is littered with failures. Tissue quality, poor clinical information, small sample numbers and lack of validation cohorts are just a few reasons for failure. It is clear that the surgeon involved in tissue acquisition must be fully engaged in the process of biosampling for a specific condition, as this will negate many of the issues for translational research failure due to an inadequate bioresource.APPROACH: In this Matter for Debate paper, the Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC) is discussed as an example of a urological surgery lead bioresource which has resulted in a National collection of renal cancer tissue and blood (from over 900 patients to date), negating all of the traditional issues with biobanks because of close enagagement and acknowledgement of urologists and uropathologists from seven centres around Scotland. SCOTRRCC has leveraged renal cancer research in Scotland resulting in several high impact publications and providing a springboard for future research in this disease in Scotland and beyond.CONCLUSIONS: The SCOTRRCC model presented here can be transferred to other surgical disciplines for success in translational research.

AB - BACKGROUND: High quality human biosamples with associated high quality clinical data are essential for successful translational research. Despite this, the traditional approach is for the surgeon to act as a technician in the tissue collection act. Biomarker research presents multiple challenges and the field is littered with failures. Tissue quality, poor clinical information, small sample numbers and lack of validation cohorts are just a few reasons for failure. It is clear that the surgeon involved in tissue acquisition must be fully engaged in the process of biosampling for a specific condition, as this will negate many of the issues for translational research failure due to an inadequate bioresource.APPROACH: In this Matter for Debate paper, the Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC) is discussed as an example of a urological surgery lead bioresource which has resulted in a National collection of renal cancer tissue and blood (from over 900 patients to date), negating all of the traditional issues with biobanks because of close enagagement and acknowledgement of urologists and uropathologists from seven centres around Scotland. SCOTRRCC has leveraged renal cancer research in Scotland resulting in several high impact publications and providing a springboard for future research in this disease in Scotland and beyond.CONCLUSIONS: The SCOTRRCC model presented here can be transferred to other surgical disciplines for success in translational research.

U2 - 10.1016/j.surge.2015.03.001

DO - 10.1016/j.surge.2015.03.001

M3 - Article

C2 - 25937514

SN - 1479-666X

VL - 13

SP - 181

EP - 186

JO - The Surgeon

JF - The Surgeon

IS - 4

ER -

Translational research will fail without surgical leadership: SCOTRRCC a successful surgeon-led Nationwide translational research infrastructure in renal cancer

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