Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population

AJ Leigh Brown, SDW Frost, WC Mathews, K Dawson, NS Hellmann, ES Daar, DD Richman, SJ Little

Research output: Contribution to journalArticlepeer-review

Abstract

Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only similar to20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.
Original languageUndefined/Unknown
Pages (from-to)683-686
Number of pages4
JournalThe Journal of Infectious Diseases
Volume187
Issue number4
Publication statusPublished - 2003

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