Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population

AJ Leigh Brown; SDW Frost; WC Mathews; K Dawson; NS Hellmann; ES Daar; DD Richman; SJ Little

Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population

AJ Leigh Brown, SDW Frost, WC Mathews, K Dawson, NS Hellmann, ES Daar, DD Richman, SJ Little

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only similar to20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.

Original language	Undefined/Unknown
Pages (from-to)	683-686
Number of pages	4
Journal	The Journal of Infectious Diseases
Volume	187
Issue number	4
Publication status	Published - 2003

Cite this

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title = "Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population",

abstract = "Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only similar to20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.",

author = "{Leigh Brown}, AJ and SDW Frost and WC Mathews and K Dawson and NS Hellmann and ES Daar and DD Richman and SJ Little",

year = "2003",

language = "Undefined/Unknown",

volume = "187",

pages = "683--686",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "4",

}

Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population. / Leigh Brown, AJ; Frost, SDW; Mathews, WC; Dawson, K; Hellmann, NS; Daar, ES; Richman, DD; Little, SJ.

In: The Journal of Infectious Diseases, Vol. 187, No. 4, 2003, p. 683-686.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population

AU - Leigh Brown, AJ

AU - Frost, SDW

AU - Mathews, WC

AU - Dawson, K

AU - Hellmann, NS

AU - Daar, ES

AU - Richman, DD

AU - Little, SJ

PY - 2003

Y1 - 2003

N2 - Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only similar to20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.

AB - Although the prevalence of drug-resistant strains in primary human immunodeficiency virus (HIV) infection in North America has recently increased, their transmission fitness remains unknown. The present study estimated the frequency of transmission of drug-resistant HIV from patients receiving antiretroviral therapy using retrospective surveys of clinic data. It revealed that resistant virus was transmitted only similar to20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains.

M3 - Article

VL - 187

SP - 683

EP - 686

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 4

ER -