Treating aortic stenosis: arresting the snowball effect

Tania A Pawade, David E Newby

Research output: Contribution to journalLiterature reviewpeer-review


Aortic stenosis is common and potentially fatal. Recent key insights into the pathophysiology of this disease suggest it is likely to represent a self-perpetuating cycle of injury where tissue calcification is the major driver. Also, the mechanisms governing this appear closely related to calcium homeostasis and bone metabolism. Manipulation of these processes may offer a means by which aortic stenosis progression can be inhibited using drugs currently licensed to treat osteoporosis. Indeed, a prospective randomized controlled trial is currently underway for determining whether denosumab or bisphosphonates can slow aortic stenosis disease. If successful, this would meet a major unmet clinical need.

Original languageEnglish
Pages (from-to)461-3
Number of pages3
JournalExpert Review of Cardiovascular Therapy
Issue number5
Publication statusPublished - May 2015


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