Treatment of neonatal sepsis with intravenous immune globulin

INIS Collaborative Group, Peter Brocklehurst, Barbara Farrell, Andrew King, Edmund Juszczak, Brian Darlow, Khalid Haque, Alison Salt, Ben Stenson, William Tarnow-Mordi

Research output: Contribution to journalArticlepeer-review

Abstract

Neonatal sepsis is a major cause of death and complications despite antibiotic treatment. Effective adjunctive treatments are needed. Newborn infants are relatively deficient in endogenous immunoglobulin. Meta-analyses of trials of intravenous immune globulin for suspected or proven neonatal sepsis suggest a reduced rate of death from any cause, but the trials have been small and have varied in quality.
Original languageEnglish
Pages (from-to)1201-11
Number of pages11
JournalNew England Journal of Medicine
Volume365
Issue number13
DOIs
Publication statusPublished - 29 Sep 2011

Keywords

  • Double-Blind Method
  • Immunologic Factors
  • Humans
  • Infant, Newborn
  • Recurrence
  • Drug Therapy, Combination
  • Staphylococcal Infections
  • Anti-Bacterial Agents
  • Risk
  • Gram-Positive Bacterial Infections
  • Sepsis
  • Immunoglobulins, Intravenous
  • Female
  • Male

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