Trends in glycaemic control and drug use in males and females with type 2 diabetes mellitus: the results of the Australian National Diabetes Audit (ANDA) 2013-2019

AS Xiang, N Szwarcbard, Danijela Gasevic, A Earnest, A Pease, S Andrikopoulos, N Wischer, W. Davis, Sophia Zoungas

Research output: Contribution to journalArticlepeer-review

Abstract

Aims There has been considerable change in the management of type 2 diabetes over the previous decade with the introduction of several novel anti-hyperglycaemic agents and drug preparations. Here we investigated temporal changes in glycaemic control and use of anti-hyperglycaemic therapies in females and males with type 2 diabetes between 2013 to 2019. Methods Data from adult patients with type 2 diabetes (n=11,930; 44.9% females, mean (SD) age of 63.0 (12.9) years) were analysed from the 2013 to 2019 biennial cross-sectional Australian National Diabetes Audits (ANDA). Results Mean HbA1c remained similar throughout the years examined and between sexes (between 7.8% – 8.3%, 62 – 67 mmol/mol; p >0.05). The number of anti-hyperglycaemic agents used by both sexes increased between 2013 to 2019 (p <0.001) with more agents used by males (p = 0.014). Between 2013 and 2019, there were increasing proportions of both sexes using DPP-4 inhibitors (females: 11.7% to 25.7%, p = 0.045 males: 11.6% to 29.5%, p = 0.036) and GLP-1-agonists (females: 5.9% to 15.3%; males: 4.9% to 11.1%, p = 0.043 for both). SGLT2 inhibitors were not available in 2013, however their use increased substantially between 2015 and 2019 in both females (4.9% to 26.3%, p = 0.013) and males (4.7% to 32.2, p = 0.019). Conclusions Between 2013 and 2019, mean HbA1c levels remained unchanged despite a concurrent increase in the number of anti-hyperglycaemic medications used. Overall, there was a trend towards preferencing newer agents with some differences in treatment regimens relating to sex and renal function.
Original languageEnglish
JournalDiabetes, Obesity and Metabolism
Early online date2 Aug 2021
DOIs
Publication statusE-pub ahead of print - 2 Aug 2021

Fingerprint

Dive into the research topics of 'Trends in glycaemic control and drug use in males and females with type 2 diabetes mellitus: the results of the Australian National Diabetes Audit (ANDA) 2013-2019'. Together they form a unique fingerprint.

Cite this