Tripotential differentiation of adherently expandable neural stem (NS) cells

Tamara Glaser, Steven M Pollard, Austin Smith, Oliver Brüstle

Research output: Contribution to journalArticlepeer-review

Abstract

A recent study has shown that pure neural stem cells can be derived from embryonic stem (ES) cells and primary brain tissue. In the presence of fibroblast growth factor 2 (FGF2) and epidermal growth factor (EGF), this population can be continuously expanded in adherent conditions. In analogy to continuously self-renewing ES cells, these cells were termed 'NS' cells (Conti et al., PLoS Biol 3: e283, 2005). While NS cells have been shown to readily generate neurons and astrocytes, their differentiation into oligodendrocytes has remained enigmatic, raising concerns as to whether they truly represent tripotential neural stem cells.
Original languageEnglish
Pages (from-to)e298
JournalPLoS ONE
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • Animals
  • Cell Differentiation
  • Cell Division
  • Cell Transplantation
  • Cells, Cultured
  • Colforsin
  • Epidermal Growth Factor
  • Fibroblast Growth Factor 2
  • Myelin Sheath
  • Neurons
  • Platelet-Derived Growth Factor
  • Rats
  • Stem Cell Transplantation
  • Stem Cells

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