Projects per year
Abstract
Being recognized as the best-tolerated of all metals, the catalytic potential of gold (Au) has thus far been hindered by the ubiquitous presence of thiols in organisms. Herein we report the development of a truly-catalytic Au-polymer composite by assembling ultrasmall Au-nanoparticles at the protein-repelling outer layer of a co-polymer scaffold via electrostatic loading. Illustrating the in vivo-compatibility of the novel catalysts, we show their capacity to uncage the anxiolytic agent fluoxetine at the central nervous system (CNS) of developing zebrafish, influencing their swim pattern. This bioorthogonal strategy has enabled - for the first time - modification of cognitive activity by releasig a neuroactive agent directly in the brain of an animal.
Original language | English |
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Journal | Angewandte Chemie |
Early online date | 3 Nov 2021 |
DOIs | |
Publication status | E-pub ahead of print - 3 Nov 2021 |
Fingerprint
Dive into the research topics of 'Truly-biocompatible gold catalysis enables vivo-orthogonal intra-CNS release of anxiolytics'. Together they form a unique fingerprint.Projects
- 2 Finished
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Bioorthogonal Gold Chemistry To Explore Novel Biomedical Applications
1/10/18 → 31/03/22
Project: Research
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Locally-Controlled Activation of Chemotherapeutics by Palladium Catalysis as a Novel Anticancer Technology
Unciti-Broceta, A. & Brennan, P.
1/04/16 → 30/09/21
Project: Research
Equipment
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Edinburgh Drug Discovery
Asier Unciti-Broceta (Manager), Scott Webster (Manager) & Neil Carragher (Manager)
Deanery of Molecular, Genetic and Population Health SciencesFacility/equipment: Facility