Tumour-associated macrophages are associated with vascular endothelial growth factor expression in canine mammary tumours

T P Raposo, I Pires, M I Carvalho, J Prada, D J Argyle, F L Queiroga

Research output: Contribution to journalArticlepeer-review

Abstract

Tumour-associated macrophages (TAMs) have been implicated in carcinogenesis including an important role in angiogenesis. In this study, we describe the relationship between TAMs and angiogenesis in canine mammary tumours (CMT). Formalin-fixed paraffin-embedded CMT samples [(n = 128: malignant (n = 97) and benign (n = 31)] were submitted to immunohistochemical staining to detect MAC387, vascular endothelial growth factor VEGF and CD31 expression. A statistical analysis was carried out to assess possible associations with clinicopathological variables and biological markers of tumour angiogenesis. TAMs, detected by MAC387 expression, were significantly associated with malignant CMT (P
Original languageEnglish
Pages (from-to)464-474
JournalVeterinary and Comparative Oncology
Volume13
Issue number4
Early online date4 Oct 2013
DOIs
Publication statusPublished - Dec 2015

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