Projects per year
Neurons important for cognitive function are often classified by their morphology and integrative properties. However, it is unclear if within a single class of neuron these properties tune synaptic responses to the salient features of the information that each neuron represents. We demonstrate that for stellate neurons in layer 11 of the medial entorhinal cortex, the waveform of postsynaptic potentials, the time window for detection of coincident inputs, and responsiveness to gamma frequency inputs follow a dorsal-ventral gradient similar to the topographical organization of grid-like spatial firing fields of neurons in this area. We provide evidence that these differences are due to a membrane conductance gradient mediated by HCN and leak potassium channels. These findings suggest key roles for synaptic integration in computations carried out within the medial entorhinal cortex and imply that tuning of neural information processing by membrane ion channels is important for normal cognitive function.
- Bone and Bones/ chemistry
- Creutzfeldt-Jakob Syndrome/prevention & control/transmission
- Encephalopathy, Bovine Spongiform/prevention & control/transmission
- Gelatin/ chemistry
- Hot Temperature
- Prions/ pathogenicity
- Time Factors
FingerprintDive into the research topics of 'Tuning of Synaptic Integration in the Medial Entorhinal Cortex to the Organization of Grid Cell Firing Fields'. Together they form a unique fingerprint.
- 2 Finished
Dendrites and Memory: Behavioural roles for information processing in the dendrites of cortical neurons
1/01/07 → 31/12/10
1/09/06 → 31/07/11