Two interlinked bistable switches govern mitotic control in mammalian cells

Scott Rata, Maria F. Suarez Peredo Rodriguez, Stephy Joseph, Nisha Peter, Fabio Echegaray Iturra, Fengwei Yang, Anotida Madzvamuse, Jan G. Ruppert, Kumiko Samejima, Melpomeni Platani, Monica Alvarez-Fernandez, Marcos Malumbres, William C. Earnshaw, Bela Novak*, Helfrid Hochegger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Rata et al. combine quantitative assays with mathematical modeling to show that hysteresis of the mitotic switch emerges from mutual effects of Cdk1 and its counteracting phosphatase, PP2A:B55, on each other's auto-activation loops. Their work also reveals an intermediate but hidden steady state between interphase and M phase.

Original languageEnglish
Pages (from-to)3824-3832.e6
JournalCurrent Biology
Issue number23
Early online date15 Nov 2018
Publication statusPublished - 3 Dec 2018


  • bistability
  • Cdk1-Cyclin B
  • cell cycle
  • greatwall-kinase
  • HeLa Cdk1as cell line
  • hysteresis
  • mitosis
  • mitotic control
  • PP2A-B55


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