Projects per year
Abstract
The way in which photons travel through biological tissues and subsequently become scattered or absorbed is a key limitation for traditional optical medical imaging techniques using visible light. In contrast, near-infrared wavelengths, in particular those above 1000 nm, penetrate deeper in tissues and undergo less scattering and cause less photo-damage, which describes the so-called “second biological transparency window”. Unfortunately, current dyes and imaging probes have severely limited absorption profiles at such long wavelengths, and molecular engineering of novel NIR-II dyes can be a tedious and unpredictable process, which limits access to this optical window and impedes further developments. Two-photon (2P) absorption not only provides convenient access to this window by doubling the absorption wavelength of dyes, but also increases the possible resolution. This review aims to provide an update on the available 2P instrumentation and 2P luminescent materials available for optical imaging in the NIR-II window.
Original language | English |
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Article number | 921354 |
Pages (from-to) | 921354 |
Journal | Frontiers in chemistry |
Volume | 10 |
Early online date | 24 Jun 2022 |
DOIs | |
Publication status | Published - 24 Jun 2022 |
Keywords / Materials (for Non-textual outputs)
- fluorescent imaging
- infrared dyes
- near-infrared II
- pulsed lasers
- tissue penetration
- two-photon absorption
- two-photon microscopy
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Lighting the Way to a Healthy Nation - Optical 'X-rays' for Walk Through Diagnosis & Therapy
Bradley, M.
1/06/20 → 31/05/25
Project: Research
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IRC Next Steps Plus: Photonic Pathogen Theranostics - Point-of-care image guided photonic therapy of bacterial and fungal infection?
Dhaliwal, K., Bradley, M., Harrison, E., Megia Fernandez, A., Mills, B., Walsh, T. & Williams, G.
1/07/19 → 30/06/23
Project: Research
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EPSRC IRC Proteus - Multiplexed 'Touch and Tell' Optical Molecular Sensing and Imaging - Lifetime and Beyond
Bradley, M.
1/01/19 → 31/12/22
Project: Research