Two structures of cyclophilin 40: folding and fidelity in the TPR domains

P Taylor, J Dornan, A Carrello, R F Minchin, T Ratajczak, M D Walkinshaw

Research output: Contribution to journalArticlepeer-review

Abstract

The "large immunophilin" family consists of domains of cyclophilin or FK506 binding protein linked to a tetratricopeptide (TPR) domain. They are intimately associated with steroid receptor complexes and bind to the C-terminal domain of Hsp90 via the TPR domain. The competitive binding of specific large immunophilins and other TPR-Hsp90 proteins provides a regulatory mechanism for Hsp90 chaperone activity.
Original languageEnglish
Pages (from-to)431-8
Number of pages8
JournalStructure
Volume9
Issue number5
Publication statusPublished - 2001

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