Abstract / Description of output
Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.
Original language | English |
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Pages (from-to) | 607-614 |
Number of pages | 8 |
Journal | Nature Reviews Immunology |
Volume | 13 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2013 |
Keywords / Materials (for Non-textual outputs)
- alternatively activated macrophages
- haemaphysalis-longicornis ticks
- induced pulmonary inflammation
- dendritic cell-function
- regulatory t cells
- hygiene hypothesis
- gene-expression
- lymphoid-cells
- TH2 responses
- murine schistosomiasis