Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths

William C. Gause*, Thomas A. Wynn, Judith E. Allen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Helminth-induced type 2 immune responses, which are characterized by the T helper 2 cell-associated cytokines interleukin-4 (IL-4) and IL-13, mediate host protection through enhanced tissue repair, the control of inflammation and worm expulsion. In this Opinion article, we consider type 2 immunity in the context of helminth-mediated tissue damage. We examine the relationship between the control of helminth infection and the mechanisms of wound repair, and we provide a new understanding of the adaptive type 2 immune response and its contribution to both host tolerance and resistance.

Original languageEnglish
Pages (from-to)607-614
Number of pages8
JournalNature Reviews Immunology
Volume13
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • alternatively activated macrophages
  • haemaphysalis-longicornis ticks
  • induced pulmonary inflammation
  • dendritic cell-function
  • regulatory t cells
  • hygiene hypothesis
  • gene-expression
  • lymphoid-cells
  • TH2 responses
  • murine schistosomiasis

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