Type 2 Innate Lymphoid Cells Drive CD4+ Th2 Cell Responses

Ananda S. Mirchandani, Anne-Gaelle Besnard, Edwin Yip, Charlotte Scott, Calum C. Bain, Vuk Cerovic, Robert J. Salmond, Foo Y. Liew

Research output: Contribution to journalArticlepeer-review


CD4+ T cells have long been grouped into distinct helper subsets on the basis of their cytokine-secretion profile. In recent years, several subsets of innate lymphoid cell have been described as key producers of these same Th-associated cytokines. However, the functional relationship between Th cells and innate lymphoid cells (ILCs) remains unclear. We show in this study that lineage-negative ST2+ICOS+CD45+ type 2 ILCs and CD4+ T cells can potently stimulate each other’s function via distinct mechanisms. CD4+ T cell provision of IL-2 stimulates type 2 cytokine production by type 2 ILCs. By contrast, type 2 ILCs modulate naive T cell activation in a cell contact–dependent manner, favoring Th2 while suppressing Th1 differentiation. Furthermore, a proportion of type 2 ILCs express MHC class II and can present peptide Ag in vitro. Importantly, cotransfer experiments show that type 2 ILCs also can boost CD4+ T cell responses to Ag in vivo.
Original languageEnglish
Pages (from-to)2442-2448
Number of pages7
JournalJournal of Immunology
Issue number5
Early online date27 Jan 2014
Publication statusPublished - 1 Mar 2014


  • Animals
  • Antigens, Differentiation
  • Cell Differentiation
  • Cytokines
  • Histocompatibility Antigens Class II
  • Immunity, Innate
  • Mice
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Th1 Cells
  • Th2 Cells


Dive into the research topics of 'Type 2 Innate Lymphoid Cells Drive CD4+ Th2 Cell Responses'. Together they form a unique fingerprint.

Cite this