Ubiquitination of the human immunodeficiency virus type 1 Env glycoprotein

A Bultmann, J Eberle, J Haas

Research output: Contribution to journalArticlepeer-review

Abstract

Expression of the human immunodeficiency virus type 1 (HIV-1) Env glycoprotein is stringently regulated in infected cells, The majority of the glycoprotein does not reach the cell surface but rather is retained in the endoplasmic reticulum or a cis-Golgi compartment and subsequently degraded. We here report that Env of various HIV-1 isolates is ubiquitinated at the extracellular domain of gp41 and that Env expression could be increased by lactacystin, a specific proteasome inhibitor, suggesting that the ubiquitin/proteasome system is involved in control of expression and degradation.

Original languageEnglish
Pages (from-to)5373-5376
Number of pages4
JournalJournal of Virology
Volume74
Issue number11
DOIs
Publication statusPublished - Jun 2000

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