Abstract / Description of output
Expression of the human immunodeficiency virus type 1 (HIV-1) Env glycoprotein is stringently regulated in infected cells, The majority of the glycoprotein does not reach the cell surface but rather is retained in the endoplasmic reticulum or a cis-Golgi compartment and subsequently degraded. We here report that Env of various HIV-1 isolates is ubiquitinated at the extracellular domain of gp41 and that Env expression could be increased by lactacystin, a specific proteasome inhibitor, suggesting that the ubiquitin/proteasome system is involved in control of expression and degradation.
Original language | English |
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Pages (from-to) | 5373-5376 |
Number of pages | 4 |
Journal | Journal of Virology |
Volume | 74 |
Issue number | 11 |
DOIs | |
Publication status | Published - Jun 2000 |