Ubiquitylation and degradation of elongating RNA polymerase II: The last resort

Marcus D. Wilson, Michelle Harreman, Jesper Q. Svejstrup*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

During its journey across a gene, RNA polymerase II has to contend with a number of obstacles to its progression, including nucleosomes, DNA-binding proteins, DNA damage, and sequences that are intrinsically difficult to transcribe. Not surprisingly, a large number of elongation factors have evolved to ensure that transcription stalling or arrest does not occur. If, however, the polymerase cannot be restarted, it becomes poly-ubiquitylated and degraded by the proteasome. This process is highly regulated, ensuring that only RNAPII molecules that cannot otherwise be salvaged are degraded. In this review, we describe the mechanisms and factors responsible for the last resort mechanism of transcriptional elongation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalBBA - Gene Regulatory Mechanisms
Issue number1
Publication statusPublished - 1 Jan 2013

Keywords / Materials (for Non-textual outputs)

  • Elongin
  • NEDD4
  • RNA polymerase II
  • Rsp5
  • Transcript elongation
  • Ubiquitin


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