UK consensus guidelines for the use of the protease inhibitors boceprevir and telaprevir in genotype 1 chronic hepatitis C infected patients

P. Ramachandran, A. Fraser, K. Agarwal, A. Austin, A. Brown, G. R. Foster, R. Fox, P. C. Hayes, C. Leen, P. R. Mills, D. J. Mutimer, S. D. Ryder, J. F. Dillon

Research output: Contribution to journalArticlepeer-review



The nonstructural 3 serine protease inhibitors (PIs), boceprevir and telaprevir, represent the first in a new generation of directly acting antivirals against genotype 1 hepatitis C (HCV) infection. When used in combination with pegylated interferon and ribavirin, these drugs greatly improve sustained virological response rates in both treatment-na ve patients and patients who have had previous virological failure on treatment. However, the addition of these new agents will increase the complexity of therapeutic regimens, the rates of side-effects and costs.


To review concisely the current evidence and to suggest current best practice, for the use of telaprevir and boceprevir in the management of chronic genotype 1 HCV infection.


These guidelines for the use of boceprevir and telaprevir have been formulated following extensive review of the current literature, are based on the consensus opinion of a panel of national experts, and have been openly discussed and debated at a national meeting of HCV care providers.


We have made recommendations on a number of the key practical issues facing HCV care providers: (i) Which patients to treat?; (ii) Standards for the provision of care; (iii) Pre-treatment considerations; (iv) Which treatment regimens to use?; (v) Stopping rules; and (vi) Management of adverse effects. Finally, we have produced suggested algorithms for the assessment and treatment of these patients.


These UK Consensus guidelines indicate the current best practice for the use of boceprevir and telaprevir in the management of genotype 1 chronic HCV infection.

Original languageEnglish
Pages (from-to)647-662
Number of pages16
JournalAlimentary Pharmacology and Therapeutics
Issue number6
Publication statusPublished - Mar 2012


  • Algorithms
  • Antiviral Agents
  • Drug Therapy, Combination
  • Genotype
  • Great Britain
  • Hepacivirus
  • Hepatitis C, Chronic
  • Humans
  • Interferon-alpha
  • Oligopeptides
  • Patient Selection
  • Polyethylene Glycols
  • Proline
  • Randomized Controlled Trials as Topic
  • Recombinant Proteins
  • Ribavirin
  • Serine Proteinase Inhibitors
  • Viral Load

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