Ultrastable shelled PFC nanobubbles: a platform for ultrasound-assisted diagnostics and therapy

Patrizia Nadia Hanieh, Caterina Ricci, Andrea Bettucci, Roberto Marotta, Carmel M Moran, Laura Cantù, Maria Carafa, Federica Rinaldi*, Elena Del Favero*, Carlotta Marianecci

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Nanoscale echogenic bubbles (NBs), can be used as a theranostic platform for the localized
delivery of encapsulated drugs. However, the generation of NBs is challenging, because they have
lifetimes as short as milliseconds in solution. The aim of this work has been the optimization of a
preparation method for the generation of stable NBs, characterized by measuring: a) acoustic
efficiency, b) nano-size, to ensure passive tumour targeting, c) stability during storage and after
injection d) ability to entrap drugs. NBs are monodisperse and ultra-stable, their stability achieved
by generation of an amphiphilic multilamellar shell able to efficiently retain the PFC gas. The NBs
perform as good acoustic enhancers over a wide frequency range and out of resonant conditions,
as tested in both in vitro and in vivo experiments, proving to be a potential platform for the
production of versatile carriers to be used in ultrasound-assisted diagnostic, therapeutic and
theranostic applications.

Original languageEnglish
JournalNanomedicine: Nanotechnology, Biology and Medicine
Early online date10 Oct 2022
Publication statusE-pub ahead of print - 10 Oct 2022

Keywords / Materials (for Non-textual outputs)

  • Nanobubbles
  • ultrasound contrast agents
  • acoustics
  • theranostics
  • Drug delivery


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