Ultrastructural analysis of the florid plaque in variant Creutzfeldt-Jakob disease

P P Liberski, J Ironside, L McCardle, A Sherring

Research output: Contribution to journalArticlepeer-review


We report here the first description of florid plaques--the hallmark of variant Creutzfeldt-Jakob disease (vCJD). These plaques are composed of broad bundles of amyloid, are highly neuritic and exhibited astrocytes and microglial cells. Collectively, they are more similar to neuritic plaques of Alzheimer's disease than to kuru plaques of kuru--Creutzfeldt-Jakob disease--Gerstmann-Sträussler-Sheinker disease.

Original languageEnglish
Pages (from-to)167-70
Number of pages4
JournalFolia Neuropathologica
Issue number4
Publication statusPublished - 2000


  • Alzheimer Disease
  • Amyloid
  • Astrocytes
  • Brain
  • Creutzfeldt-Jakob Syndrome
  • Humans
  • Kuru
  • Microglia
  • Microscopy, Electron
  • Neurites
  • Plaque, Amyloid

Fingerprint Dive into the research topics of 'Ultrastructural analysis of the florid plaque in variant Creutzfeldt-Jakob disease'. Together they form a unique fingerprint.

Cite this