Ultrastructural analysis of the florid plaque in variant Creutzfeldt-Jakob disease

P P Liberski, J Ironside, L McCardle, A Sherring

Research output: Contribution to journalArticlepeer-review

Abstract

We report here the first description of florid plaques--the hallmark of variant Creutzfeldt-Jakob disease (vCJD). These plaques are composed of broad bundles of amyloid, are highly neuritic and exhibited astrocytes and microglial cells. Collectively, they are more similar to neuritic plaques of Alzheimer's disease than to kuru plaques of kuru--Creutzfeldt-Jakob disease--Gerstmann-Sträussler-Sheinker disease.

Original languageEnglish
Pages (from-to)167-70
Number of pages4
JournalFolia Neuropathologica
Volume38
Issue number4
Publication statusPublished - 2000

Keywords

  • Alzheimer Disease
  • Amyloid
  • Astrocytes
  • Brain
  • Creutzfeldt-Jakob Syndrome
  • Humans
  • Kuru
  • Microglia
  • Microscopy, Electron
  • Neurites
  • Plaque, Amyloid

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