Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma

P P Liberski, P Rodgers-Johnson, R Yanagihara, J W Lee, B S Kramer, P Piccardo, C A Mora, C J Gibbs, D C Gajdusek

Research output: Contribution to journalArticlepeer-review

Abstract

A white patient with human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia/lymphoma for 10 years died 4 months after the onset of spastic myelopathy. Ultrastructurally, the neuropathologic findings consisted of dystrophic neurites (spheroids) filled with neurofilaments or electron-dense bodies, intense astrocytic reaction with abundant formation of corpora amylacea, and multilamellar bodies. Demyelination and spongiform change were absent. Viruslike particles resembling HTLV-I were detected adjacent to brain endothelial cells.

Original languageEnglish
Pages (from-to)511-8
Number of pages8
JournalUltrastructural pathology
Volume18
Issue number5
Publication statusPublished - 1 Sep 1994

Keywords

  • Human T-lymphotropic virus 1
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Paraparesis, Tropical Spastic
  • Spinal Cord

Fingerprint

Dive into the research topics of 'Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma'. Together they form a unique fingerprint.

Cite this