Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma

P P Liberski; P Rodgers-Johnson; R Yanagihara; J W Lee; B S Kramer; P Piccardo; C A Mora; C J Gibbs; D C Gajdusek

Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma

P P Liberski, P Rodgers-Johnson, R Yanagihara, J W Lee, B S Kramer, P Piccardo, C A Mora, C J Gibbs, D C Gajdusek

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

A white patient with human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia/lymphoma for 10 years died 4 months after the onset of spastic myelopathy. Ultrastructurally, the neuropathologic findings consisted of dystrophic neurites (spheroids) filled with neurofilaments or electron-dense bodies, intense astrocytic reaction with abundant formation of corpora amylacea, and multilamellar bodies. Demyelination and spongiform change were absent. Viruslike particles resembling HTLV-I were detected adjacent to brain endothelial cells.

Original language	English
Pages (from-to)	511-8
Number of pages	8
Journal	Ultrastructural pathology
Volume	18
Issue number	5
Publication status	Published - 1 Sept 1994

Keywords / Materials (for Non-textual outputs)

Human T-lymphotropic virus 1
Humans
Leukemia-Lymphoma, Adult T-Cell
Male
Microscopy, Electron
Middle Aged
Paraparesis, Tropical Spastic
Spinal Cord

Cite this

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title = "Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma",

abstract = "A white patient with human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia/lymphoma for 10 years died 4 months after the onset of spastic myelopathy. Ultrastructurally, the neuropathologic findings consisted of dystrophic neurites (spheroids) filled with neurofilaments or electron-dense bodies, intense astrocytic reaction with abundant formation of corpora amylacea, and multilamellar bodies. Demyelination and spongiform change were absent. Viruslike particles resembling HTLV-I were detected adjacent to brain endothelial cells.",

keywords = "Human T-lymphotropic virus 1, Humans, Leukemia-Lymphoma, Adult T-Cell, Male, Microscopy, Electron, Middle Aged, Paraparesis, Tropical Spastic, Spinal Cord",

author = "Liberski, {P P} and P Rodgers-Johnson and R Yanagihara and Lee, {J W} and Kramer, {B S} and P Piccardo and Mora, {C A} and Gibbs, {C J} and Gajdusek, {D C}",

year = "1994",

month = sep,

day = "1",

language = "English",

volume = "18",

pages = "511--8",

journal = "Ultrastructural pathology",

issn = "0191-3123",

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TY - JOUR

T1 - Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma

AU - Liberski, P P

AU - Rodgers-Johnson, P

AU - Yanagihara, R

AU - Lee, J W

AU - Kramer, B S

AU - Piccardo, P

AU - Mora, C A

AU - Gibbs, C J

AU - Gajdusek, D C

PY - 1994/9/1

Y1 - 1994/9/1

N2 - A white patient with human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia/lymphoma for 10 years died 4 months after the onset of spastic myelopathy. Ultrastructurally, the neuropathologic findings consisted of dystrophic neurites (spheroids) filled with neurofilaments or electron-dense bodies, intense astrocytic reaction with abundant formation of corpora amylacea, and multilamellar bodies. Demyelination and spongiform change were absent. Viruslike particles resembling HTLV-I were detected adjacent to brain endothelial cells.

AB - A white patient with human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia/lymphoma for 10 years died 4 months after the onset of spastic myelopathy. Ultrastructurally, the neuropathologic findings consisted of dystrophic neurites (spheroids) filled with neurofilaments or electron-dense bodies, intense astrocytic reaction with abundant formation of corpora amylacea, and multilamellar bodies. Demyelination and spongiform change were absent. Viruslike particles resembling HTLV-I were detected adjacent to brain endothelial cells.

KW - Human T-lymphotropic virus 1

KW - Humans

KW - Leukemia-Lymphoma, Adult T-Cell

KW - Male

KW - Microscopy, Electron

KW - Middle Aged

KW - Paraparesis, Tropical Spastic

KW - Spinal Cord

M3 - Article

C2 - 7810002

SN - 0191-3123

VL - 18

SP - 511

EP - 518

JO - Ultrastructural pathology

JF - Ultrastructural pathology

IS - 5

ER -

Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma

Abstract

Keywords / Materials (for Non-textual outputs)

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