Uncovering the genetic architecture of major depression

Andrew McIntosh; Patrick F. Sullivan; Cathryn M. Lewis

doi:10.1016/j.neuron.2019.03.022

Uncovering the genetic architecture of major depression

Andrew McIntosh, Patrick F. Sullivan, Cathryn M. Lewis

Research output: Contribution to journal › Review article › peer-review

Original language	English
Journal	Neuron
Early online date	3 Apr 2019
DOIs	https://doi.org/10.1016/j.neuron.2019.03.022
Publication status	E-pub ahead of print - 3 Apr 2019

Access to Document

10.1016/j.neuron.2019.03.022

McIntosh_Genetic architecture of major depression
This is the authors' peer-reviewed manuscript as accepted for publication.
Accepted author manuscript, 8.21 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)
Figure_1Accepted author manuscript, 16 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)
Figure_2Accepted author manuscript, 16 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

3 Finished

Leveraging routinely collected and linked research data to study the causes and consequences of common mental disorders
McIntosh, A. (Principal Investigator), Crompton, C. (Co-investigator), Fletcher-Watson, S. (Co-investigator), Lawrie, S. (Co-investigator) & Whalley, H. (Co-investigator)
MRC
31/03/18 → 30/03/20
Project: Research
A Network for Studying Psychological Resilience in Low- and Middle-Income Countries (NESP)
McIntosh, A. (Principal Investigator), Ecks, S. (Co-investigator), Grant, L. (Co-investigator), Harper, I. (Co-investigator), Jain, S. (Co-investigator), Lawrie, S. (Co-investigator), Macbeth, A. (Co-investigator), Pagliari, C. (Co-investigator), Pickersgill, M. (Co-investigator) & Wolters, M. (Co-investigator)
MRC
1/03/18 → 31/05/19
Project: Research
Stratifying Resilience and Depression Longitudinally
McIntosh, A. (Principal Investigator), Deary, I. (Co-investigator), Evans, K. (Co-investigator), Haley, C. (Co-investigator) & Porteous, D. (Co-investigator)
UK-based charities
1/01/15 → 30/06/21
Project: Research

2 Article

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Howard, D. M., Adams, M. J., Clarke, T.-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., Alloza, C., Shen, X., Barbu, M. C., Xu, E. Y., Whalley, H. C., Marioni, R. E., Porteous, D. J., Davies, G., Deary, I. J. & Hemani, G. & 20 others, Berger, K., Teismann, H., Rawal, R., Arolt, V., Baune, B. T., Dannlowski, U., Domschke, K., Tian, C., Hinds, D. A., 23andMe Research Team, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Trzaskowski, M., Byrne, E. M., Ripke, S., Smith, D. J., Sullivan, P. F., Wray, N. R., Breen, G., Lewis, C. M. & McIntosh, A. M., 31 Mar 2019, In: Nature Neuroscience. 22, 3, p. 343–352 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
eQTLGen Consortium, 23andMe Research Team, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. M. F., Bacanu, S.-A., Bækvad-Hansen, M., Beekman, A. F. T., Bigdeli, T. B., Binder, E. B., Blackwood, D. R. H. & Bryois, J. & 33 others, Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N., Castelao, E., Christensen, J. H., Clarke, T.-K., Coleman, J. I. R., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Crowley, C. A., Dashti, H. S., Davies, G., Deary, I. J., Degenhardt, F., Derks, E. M., Direk, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Eriksson, N., Escott-Price, V., Kiadeh, F. H. F., Finucane, H. K., Forstner, A. J., Frank, J., Hall, L. S., MacIntyre, D. J., Thomson, P. A., Hayward, C., McIntosh, A. M. & Porteous, D. J., May 2018, In: Nature Genetics. 50, 5, p. 668-681 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File

1 Public Engagement – Festival/Exhibition
1 Invited talk

Visit from the Scottish Government's Cabinet Secretary for Health and Sport
McIntosh, A. (Host), Beange, I. (Contributor), Iveson, M. (Contributor), Kirkham, E. (Contributor), Harris, M. (Contributor), Pugh, C. (Contributor), Fletcher-Watson, S. (Contributor), Stewart, R. (Contributor), Lawrie, S. (Advisor), Buchanan, C. (Contributor) & Seckl, J. (Chair)
9 Jul 2019
Activity: Participating in or organising an event types › Public Engagement – Festival/Exhibition

File
A genetic perspective on mood disorders
McIntosh, A. (Invited speaker)
28 May 2019
Activity: Academic talk or presentation types › Invited talk

Cite this

@article{be22513788bb47b8a2099e4285e11e4c,

title = "Uncovering the genetic architecture of major depression",

author = "Andrew McIntosh and Sullivan, {Patrick F.} and Lewis, {Cathryn M.}",

year = "2019",

month = apr,

day = "3",

doi = "10.1016/j.neuron.2019.03.022",

language = "English",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

}

Uncovering the genetic architecture of major depression

Access to Document

Projects

Leveraging routinely collected and linked research data to study the causes and consequences of common mental disorders

A Network for Studying Psychological Resilience in Low- and Middle-Income Countries (NESP)

Stratifying Resilience and Depression Longitudinally

Research output

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Activities

Visit from the Scottish Government's Cabinet Secretary for Health and Sport

A genetic perspective on mood disorders

Cite this