Projects per year
Abstract / Description of output
Atopic dermatitis is highly heterogeneous with respect to pathogenesis, clinical manifestations, and treatment response. There is evidence that ancestry and skin type each contribute to this heterogeneity, indicating the need to improve understanding of disease mechanisms in diverse populations. Methods to integrate multiomics studies have been well-described, but this review focuses on the importance and the strategies needed to integrate data across different ancestral groups, focusing, because of data availability, on Asian and European populations. Skin scientists and clinicians will each benefit from an understanding of how the multiple complimentary layers of omics data may inform future clinical management, from insight into disease pathogenesis and treatment targets.
Original language | English |
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Journal | Journal of Investigative Dermatology |
DOIs | |
Publication status | Published - 5 Nov 2024 |
Keywords / Materials (for Non-textual outputs)
- Epidemiology
- Epigenomics
- Genomics
- Multiethnic
- Transcriptomics
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- 1 Active
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Defining 'clinically actionable' genetic mechanisms in atopic eczema risk and resolution'
1/11/20 → 31/10/25
Project: Research