Understanding Atopic Dermatitis in Asian and European Population Cohorts Using Complementary Omics Techniques

Yik weng Yew, Marie Loh, Sara j. Brown

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Atopic dermatitis is highly heterogeneous with respect to pathogenesis, clinical manifestations, and treatment response. There is evidence that ancestry and skin type each contribute to this heterogeneity, indicating the need to improve understanding of disease mechanisms in diverse populations. Methods to integrate multiomics studies have been well-described, but this review focuses on the importance and the strategies needed to integrate data across different ancestral groups, focusing, because of data availability, on Asian and European populations. Skin scientists and clinicians will each benefit from an understanding of how the multiple complimentary layers of omics data may inform future clinical management, from insight into disease pathogenesis and treatment targets.

Original languageEnglish
JournalJournal of Investigative Dermatology
DOIs
Publication statusPublished - 5 Nov 2024

Keywords / Materials (for Non-textual outputs)

  • Epidemiology
  • Epigenomics
  • Genomics
  • Multiethnic
  • Transcriptomics

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