Understanding axial progenitor biology in vivo and in vitro

Filip J. Wymeersch, Valerie Wilson, Anestis Tsakiridis

Research output: Contribution to journalReview articlepeer-review

Abstract

The generation of the components that make up the embryonic body axis, such as the spinal cord and vertebral column, takes place in an anterior-to-posterior (head-to-tail) direction. This process is driven by the coordinated production of various cell types from a pool of posteriorly-located axial progenitors. Here, we review the key features of this process and the biology of axial progenitors, including neuromesodermal progenitors, the common precursors of the spinal cord and trunk musculature. We discuss recent developments in the in vitro production of axial progenitors and their potential implications in disease modelling and regenerative medicine.
Original languageEnglish
Article numberdev180612
JournalDevelopment
Volume148
Issue number4
DOIs
Publication statusPublished - 15 Feb 2021

Keywords

  • axis elongation
  • gastrulation
  • neuromesodermal progenitors
  • primitive streak
  • tail bud
  • pluripotent stem cells

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