TY - JOUR
T1 - Understanding diversity in telomere dynamics
AU - Monaghan, Pat
AU - Eisenberg, Dan T.A.
AU - Harrington, Lea
AU - Nussey, Dan
N1 - Funding Information:
The editors and authors wish to thank to the Leverhulme Trust for funding an International Network on Diversity in Telomere Dynamics which greatly facilitated the interdisciplinary collaborations and discussions that laid the foundations for this theme issue. We also thank all the contributors for their interesting and thoughtful papers, and for maintaining as much as possible the interdisciplinary perspective that we feel to be an important aspect. We also thank the Senior Commissioning Editor at Philosophical Transactions B, Helen Eaton, and all the reviewers, for all their help in putting this issue together.
PY - 2018/3/5
Y1 - 2018/3/5
N2 - Telomeres and their associated proteins constitute an ancient and highly conserved system to maintain chromosome stability and the integrity of the coding sequences in eukaryote genomes. They identify and protect the chromosome ends. While other linear chromosome-capping mechanisms also occur in nature [1], the telomeric system appears to be the most common. Many operational principles of this system are shared across a wide range of eukaryote species, indicative of its ancient origins. Telomere DNA generally comprises a string of a repeated, short, non-coding sequence, which is often G rich, such as TTAGGG [2]. The proximal end of the telomeric tract is double stranded, and the distal end terminates in a single-stranded overhang of the G-rich strand. The structure loops back on itself and the single-stranded section intrudes into the double-stranded telomeric DNA. Specific protein complexes, termed the shelterin and CST complexes, help to maintain the t-loop structure and regulate telomere access during DNA replication (e.g. for review, see [3]). Processes occur within cells not only to maintain telomere structure, but also to restore the loss of telomeric DNA that occurs as a natural consequence of the DNA replication process.
AB - Telomeres and their associated proteins constitute an ancient and highly conserved system to maintain chromosome stability and the integrity of the coding sequences in eukaryote genomes. They identify and protect the chromosome ends. While other linear chromosome-capping mechanisms also occur in nature [1], the telomeric system appears to be the most common. Many operational principles of this system are shared across a wide range of eukaryote species, indicative of its ancient origins. Telomere DNA generally comprises a string of a repeated, short, non-coding sequence, which is often G rich, such as TTAGGG [2]. The proximal end of the telomeric tract is double stranded, and the distal end terminates in a single-stranded overhang of the G-rich strand. The structure loops back on itself and the single-stranded section intrudes into the double-stranded telomeric DNA. Specific protein complexes, termed the shelterin and CST complexes, help to maintain the t-loop structure and regulate telomere access during DNA replication (e.g. for review, see [3]). Processes occur within cells not only to maintain telomere structure, but also to restore the loss of telomeric DNA that occurs as a natural consequence of the DNA replication process.
U2 - 10.1098/rstb.2016.0435
DO - 10.1098/rstb.2016.0435
M3 - Editorial
C2 - 29335374
AN - SCOPUS:85040658523
SN - 0962-8436
VL - 373
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
IS - 1741
M1 - 20160435
ER -