Understudied proteins: Opportunities and challenges for functional proteomics

Georg Kustatscher; Tom Collins; Anne-Claude Gingras; Tiannan Guo; Henning Hermjakob; Trey Ideker; Kathryn S Lilley; Emma Lundberg; Edward M Marcotte; Markus Ralser; Juri Rappsilber

doi:10.1038/s41592-022-01454-x

Understudied proteins: Opportunities and challenges for functional proteomics

Georg Kustatscher, Tom Collins, Anne-Claude Gingras, Tiannan Guo, Henning Hermjakob, Trey Ideker, Kathryn S Lilley, Emma Lundberg, Edward M Marcotte, Markus Ralser, Juri Rappsilber

School of Biological Sciences

Research output: Contribution to journal › Comment/debate › peer-review

Abstract / Description of output

Most research aiming at understanding the molecular foundations of life and disease has focused on a limited set of increasingly well-known proteins while the biological functions of many others remain poorly understood. We propose to form the Understudied Protein Initiative with the objective of reducing the annotation gap by systematically associating uncharacterized proteins with proteins of known function, thereby laying the groundwork for future detailed mechanistic studies.

Original language	English
Pages (from-to)	774-779
Number of pages	6
Journal	Nature Methods
Volume	19
Early online date	9 May 2022
DOIs	https://doi.org/10.1038/s41592-022-01454-x
Publication status	E-pub ahead of print - 9 May 2022

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Understudied proteins_ Nature Methods manuscriptAccepted author manuscript, 1.32 MBLicence: Creative Commons: Attribution (CC-BY)

Wellcome Centre for Cell Biology
Tollervey, D.
UK-based charities
1/12/16 → 1/12/21
Project: Research

Cite this

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title = "Understudied proteins: Opportunities and challenges for functional proteomics",

abstract = "Most research aiming at understanding the molecular foundations of life and disease has focused on a limited set of increasingly well-known proteins while the biological functions of many others remain poorly understood. We propose to form the Understudied Protein Initiative with the objective of reducing the annotation gap by systematically associating uncharacterized proteins with proteins of known function, thereby laying the groundwork for future detailed mechanistic studies.",

author = "Georg Kustatscher and Tom Collins and Anne-Claude Gingras and Tiannan Guo and Henning Hermjakob and Trey Ideker and Lilley, {Kathryn S} and Emma Lundberg and Marcotte, {Edward M} and Markus Ralser and Juri Rappsilber",

note = "Funding Information: The Wellcome Centre for Cell Biology is supported by core funding from the Wellcome Trust (grant no. 203149). ",

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doi = "10.1038/s41592-022-01454-x",

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TY - JOUR

T1 - Understudied proteins

T2 - Opportunities and challenges for functional proteomics

AU - Kustatscher, Georg

AU - Collins, Tom

AU - Gingras, Anne-Claude

AU - Guo, Tiannan

AU - Hermjakob, Henning

AU - Ideker, Trey

AU - Lilley, Kathryn S

AU - Lundberg, Emma

AU - Marcotte, Edward M

AU - Ralser, Markus

AU - Rappsilber, Juri

N1 - Funding Information: The Wellcome Centre for Cell Biology is supported by core funding from the Wellcome Trust (grant no. 203149).

PY - 2022/5/9

Y1 - 2022/5/9

N2 - Most research aiming at understanding the molecular foundations of life and disease has focused on a limited set of increasingly well-known proteins while the biological functions of many others remain poorly understood. We propose to form the Understudied Protein Initiative with the objective of reducing the annotation gap by systematically associating uncharacterized proteins with proteins of known function, thereby laying the groundwork for future detailed mechanistic studies.

AB - Most research aiming at understanding the molecular foundations of life and disease has focused on a limited set of increasingly well-known proteins while the biological functions of many others remain poorly understood. We propose to form the Understudied Protein Initiative with the objective of reducing the annotation gap by systematically associating uncharacterized proteins with proteins of known function, thereby laying the groundwork for future detailed mechanistic studies.

U2 - 10.1038/s41592-022-01454-x

DO - 10.1038/s41592-022-01454-x

M3 - Comment/debate

C2 - 35534633

SN - 1548-7091

VL - 19

SP - 774

EP - 779

JO - Nature Methods

JF - Nature Methods

ER -

Understudied proteins: Opportunities and challenges for functional proteomics

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