Understudied proteins: Opportunities and challenges for functional proteomics

Georg Kustatscher, Tom Collins, Anne-Claude Gingras, Tiannan Guo, Henning Hermjakob, Trey Ideker, Kathryn S Lilley, Emma Lundberg, Edward M Marcotte, Markus Ralser, Juri Rappsilber

Research output: Contribution to journalComment/debatepeer-review

Abstract / Description of output

Most research aiming at understanding the molecular foundations of life and disease has focused on a limited set of increasingly well-known proteins while the biological functions of many others remain poorly understood. We propose to form the Understudied Protein Initiative with the objective of reducing the annotation gap by systematically associating uncharacterized proteins with proteins of known function, thereby laying the groundwork for future detailed mechanistic studies.
Original languageEnglish
Pages (from-to)774-779
Number of pages6
JournalNature Methods
Early online date9 May 2022
Publication statusE-pub ahead of print - 9 May 2022


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