Unimodal and Crossmodal working memory binding is not differentially affected by age or Alzheimer's disease

Federica Guazzo, Richard Allen, Alan D. Baddeley , Sergio Della Sala

Research output: Contribution to journalArticlepeer-review

Abstract

Working Memory Binding (WMB) entails the integration of multiple sources of information to form and temporarily store unique representations. Information can be processed through either one (i.e., Unimodal WMB) or separate sensory modalities (i.e., Crossmodal WMB).

Objective: In this study, we investigated whether Crossmodal WMB is differentially affected by normal or pathological aging compared to Unimodal WMB.

Method: Experiment 1: 26 older and 26 younger adults recalled the target feature matching the test probe to complete a previously displayed color-shape binding (visually presented in the Unimodal condition; auditorily and visually presented in the Crossmodal condition). Experiment 2: 35 older and 35 younger adults undertook the same paradigm while carrying out articulatory suppression to limit verbal recoding. Experiment 3: 24 Alzheimer's disease (AD) patients and two groups of 24 healthy matched controls (tested respectively with the same and an increased memory load compared to the patients) were recruited to perform a similar task.

Results: Results show no age-related additional cost in Crossmodal WMB in respect to Unimodal WMB. AD patients had poor attainment in both WMB tasks regardless of specific binding condition.

Conclusion: These findings provide evidence identifying WMB per se to be impaired in AD, regardless of the type of to-be-bound material. This supports the view that WMB is a suitable cognitive marker for AD.
Original languageEnglish
Pages (from-to)420-436
Number of pages17
JournalNeuropsychology
Volume34
Issue number4
Early online date30 Jan 2020
DOIs
Publication statusPublished - 31 May 2020

Keywords

  • memory binding
  • working memory
  • Alzheimer's disease

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