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Abstract
When Ralph Steinman and Zanvil Cohn first described dendritic cells (DCs) in 1973 it took many years to convince the immunology community that these cells were truly distinct from macrophages. Almost four decades later, the DC is regarded as the key initiator of adaptive immune responses; however, distinguishing DCs from macrophages still leads to confusion and debate in the field. Here, Nature Reviews Immunology asks five experts to discuss the issue of heterogeneity in the mononuclear phagocyte system and to give their opinion on the importance of defining these cells for future research.
Original language | English |
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Pages (from-to) | 453-460 |
Number of pages | 8 |
Journal | Nature Reviews Immunology |
Volume | 10 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2010 |
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Dive into the research topics of 'Unravelling mononuclear phagocyte heterogeneity'. Together they form a unique fingerprint.Projects
- 1 Finished
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Development of a web-based resource for the macrophage research community
Freeman, T. & Hume, D.
9/11/09 → 8/02/13
Project: Research