Unravelling the Actin Cytoskeleton: A New Competitive Edge?

Andrew J. Davidson, Will Wood*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Dynamic rearrangements in the actin cytoskeleton underlie a wide range of cell behaviours, which in turn contribute to many aspects of human health including embryogenesis, cancer metastasis, wound healing, and inflammation. Precise control of the actin cytoskeleton requires the coordinated activity of a diverse set of different actin regulators. However, our current understanding of the actin cytoskeleton has focused on how individual actin regulatory pathways function in isolation from one another. Recently, competition has emerged as a means by which different actin assembly factors can influence each other's activity at the cellular level. Here such findings will be used to explore the possibility that competition within the actin cytoskeleton confers cellular plasticity and the ability to prioritise multiple conflicting stimuli.

Original languageEnglish
Pages (from-to)569-576
Number of pages8
JournalTrends In Cell Biology
Volume26
Issue number8
Early online date25 Apr 2016
DOIs
Publication statusPublished - Aug 2016

Keywords

  • ARP2/3 COMPLEX
  • WAVE-COMPLEX
  • MACROPHAGE-MIGRATION
  • FILAMENT NUCLEATION
  • ENA/VASP PROTEINS
  • CAPPING PROTEIN
  • CELL-MIGRATION
  • FISSION YEAST
  • IN-VITRO
  • PROFILIN

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