Untreated depression and tuberculosis treatment outcomes, quality of life and disability, Ethiopia

Fentie Ambaw*, Rosie Mayston, Charlotte Hanlon, Girmay Medhin, Atalay Alem

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Objective To investigate the association between comorbid depression and tuberculosis treatment outcomes, quality of life and disability in Ethiopia.Methods The study involved 648 consecutive adults treated for tuberculosis at 14 primary health-care facilities. All were assessed at treatment initiation (i.e. baseline) and after 2 and 6 months. We defined probable depression as a score of 10 or above on the nine-item Patient Health Questionnaire. Data on treatment default, failure and success and on death were obtained from tuberculosis registers. Quality of life was assessed using a visual analogue scale and we calculated disability scores using the World Health Organization’s Disability Assessment Scale. Using multivariate Poisson regression analysis, we estimated the association between probable depression at baseline and treatment outcomes and death.Results Untreated depression at baseline was independently associated with tuberculosis treatment default (adjusted risk ratio, aRR: 9.09;95% confidence interval, CI: 6.72 to 12.30), death (aRR: 2.99; 95% CI: 1.54 to 5.78), greater disability (β: 0.83; 95% CI: 0.67 to 0.99) and poorer quality of life (β: −0.07; 95% CI: −0.07 to −0.06) at 6 months. Participants with probable depression had a lower mean quality-of-life score than those without (5.0 versus 6.0, respectively; P < 0.001) and a higher median disability score (22.0 versus 14.0, respectively; P < 0.001)at 6 months.Conclusion Untreated depression in people with tuberculosis was associated with worse treatment outcomes, poorer quality of life andgreater disability. Health workers should be given the support needed to provide depression care for people with tuberculosis.
Original languageEnglish
Pages (from-to)225-296
Number of pages72
JournalBulletin of the World Health Organization
Volume96
Issue number4
Early online date5 Feb 2018
DOIs
Publication statusE-pub ahead of print - 5 Feb 2018

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