Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide

Jason M D Kalapothakis, Yana Berezovskaya, Cleidiane G Zampronio, Peter A Faull, Perdita E Barran, Helen J Cooper

Research output: Contribution to journalArticlepeer-review

Abstract

The helix-forming character of a model decapeptide, L4PL4K, is determined in the absence of solvent using ion mobility mass spectrometry, electron capture dissociation and molecular mechanics simulations. Unusual ECD fragmentation patterns dominated by b ions are attributed to helix formation upon electron capture and as a signature of conformational dynamics.
Original languageEnglish
JournalChemical Communications
DOIs
Publication statusPublished - 12 Nov 2013

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