Unweaving type I interferons in age-related neuroinflammation

David P J Hunt; Markus J Hofer

doi:10.1016/j.tins.2024.08.014

Unweaving type I interferons in age-related neuroinflammation

David P J Hunt, Markus J Hofer^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.

Original language	English
Pages (from-to)	751-752
Number of pages	2
Journal	Trends in Neurosciences
Volume	47
Issue number	10
DOIs	https://doi.org/10.1016/j.tins.2024.08.014
Publication status	E-pub ahead of print - 4 Sept 2024

Keywords / Materials (for Non-textual outputs)

Animals
Interferon Type I/metabolism
Aging/immunology
Neuroinflammatory Diseases/immunology
Humans
Brain/metabolism
Microglia/metabolism
Signal Transduction/physiology
Mice

Access to Document

10.1016/j.tins.2024.08.014

Cite this

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title = "Unweaving type I interferons in age-related neuroinflammation",

abstract = "Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.",

keywords = "Animals, Interferon Type I/metabolism, Aging/immunology, Neuroinflammatory Diseases/immunology, Humans, Brain/metabolism, Microglia/metabolism, Signal Transduction/physiology, Mice",

author = "Hunt, {David P J} and Hofer, {Markus J}",

year = "2024",

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doi = "10.1016/j.tins.2024.08.014",

language = "English",

volume = "47",

pages = "751--752",

journal = "Trends in Neurosciences",

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TY - JOUR

T1 - Unweaving type I interferons in age-related neuroinflammation

AU - Hunt, David P J

AU - Hofer, Markus J

PY - 2024/9/4

Y1 - 2024/9/4

N2 - Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.

AB - Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.

KW - Animals

KW - Interferon Type I/metabolism

KW - Aging/immunology

KW - Neuroinflammatory Diseases/immunology

KW - Humans

KW - Brain/metabolism

KW - Microglia/metabolism

KW - Signal Transduction/physiology

KW - Mice

U2 - 10.1016/j.tins.2024.08.014

DO - 10.1016/j.tins.2024.08.014

M3 - Review article

C2 - 39237428

SN - 0166-2236

VL - 47

SP - 751

EP - 752

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 10

ER -

Unweaving type I interferons in age-related neuroinflammation

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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Cite this