Update in chronic obstructive pulmonary disease: role of antioxidant and metabolizing gene polymorphisms

Ramzi Lakhdar*, Sabri Denden, Asma Kassab, Nadia Leban, Jalel Knani, Gerard Lefranc, Abelhadi Miled, Jemni Ben Chibani, Amel Haj Khelil

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by systemic and local chronic inflammation and oxidative stress. The sources of the increased oxidative stress in COPD patients derive from the increased burden of inhaled oxidants such as cigarette smoke and other forms of particulate or gaseous air pollution and from the increase in reactive oxygen species (ROS) generated by several inflammatory, immune, and structural airways cells. There is increasing evidence that genetic factors may also contribute to the pathogenesis if COPD, particularly antioxidant genes, which may confer a susceptibility to environmental insults such as cigarette smoke and thereafter development of COPD. Consequently, heme oxygenase-1 (HO-1), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), microsomal epoxide hydrolase (EPHX1), and cytochrome P450 (CYP) genetic polymorphisms may have an important role in COPD pathogenesis. In this review the authors summarized the most recent findings dealing with these antioxidant genes contributing to the free radical neutralization and xenobiotic enzymes playing a role in different phases of cell detoxification reactions related to the redox status imbalance in COPD, with an emphasis on their possible roles in disease progression.

Original languageEnglish
Pages (from-to)364-375
Number of pages12
JournalExperimental Lung Research
Volume37
Issue number6
DOIs
Publication statusPublished - Aug 2011

Keywords

  • antioxidant genes
  • COPD
  • genetic polymorphism
  • oxidative stress
  • xenobiotic enzymes
  • GLUTATHIONE-S-TRANSFERASE
  • MICROSOMAL EPOXIDE HYDROLASE
  • HEME OXYGENASE-1 GENE
  • SUPEROXIDE-DISMUTASE 3
  • HUMAN CATALASE GENE
  • OXIDATIVE STRESS
  • LUNG-FUNCTION
  • MICROSATELLITE POLYMORPHISM
  • MOLECULAR-MECHANISMS
  • TUNISIAN POPULATION

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