Update on cerebral small vessel disease – a dynamic, whole-brain disease

Yulu Shi, Joanna Wardlaw

Research output: Contribution to journalArticlepeer-review


Cerebral small vessel disease (CSVD) is a very common neurological disease in older people. It causes stroke and dementia, mood disturbance and gait problems. Since it is difficult to visualise CSVD pathologies in vivo, the diagnosis of CSVD has relied on imaging findings including white matter hyperintensities, lacunar ischaemic stroke, lacunes, microbleeds, visible perivascular spaces, and many haemorrhagic strokes. However, variations in the use of definition and terms of these features has probably caused confusion and difficulties in interpreting results of previous studies. A standardised use of terms should be encouraged in CSVD research. These CSVD features have long been regarded as different lesions, but emerging evidence has indicated that they might share some common intrinsic microvascular pathologies and therefore, because of its diffuse nature, CSVD should be regarded as a ‘whole-brain disease’. Single antiplatelet (for acute lacunar ischaemic stroke) and management of traditional risk factors still remain the most important therapeutic and preventive approach, due to limited understanding of pathophysiology in CSVD. Increasing evidence suggests that new studies should consider drugs that target endothelium and blood brain barrier to prevent and treat CSVD. Epidemiology of CSVD might differ in Asian compared to Western populations (where most results and guidelines about CSVD and stroke originate), but more community-based data and clear stratification of stroke types are required to address this.
Original languageEnglish
JournalStroke and Vascular Neurology
Early online date30 Sep 2016
Publication statusE-pub ahead of print - 30 Sep 2016


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