Update to: Study Pre-protocol for "BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study"

Paediatric Emergency Research in the UK and Ireland (PERUKI); Thomas C Williams; Steve Cunningham; Chengetai D Mpamhanga; Olivia V Swann; Simon B Drysdale; Xinxue Liu; Helen Groves; Shaun O'Hagan; Thomas Waterfield; Dalia Iskander; Mark D Lyttle; Robin Marlow; Abigail Maxwell-Hodkinson; Ian Sinha; Damian Roland

doi:10.12688/wellcomeopenres.16778.4

Update to: Study Pre-protocol for "BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study"

Paediatric Emergency Research in the UK and Ireland (PERUKI)
, Thomas C Williams
, Steve Cunningham
, Chengetai D Mpamhanga
, Olivia V Swann
, Simon B Drysdale
, Xinxue Liu
, Helen Groves
, Shaun O'Hagan
, Thomas Waterfield
, Dalia Iskander
, Mark D Lyttle
, Robin Marlow
, Abigail Maxwell-Hodkinson
, Ian Sinha
, Damian Roland

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation's decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024.

STUDY QUESTION: We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV.

METHODS AND LIKELY IMPACT: We will conduct a multi-centre study, utilising the PERUKI network used in the original BronchStart study, to assess the effectiveness of maternal vaccination using a test-negative study design. We will gather detailed clinical information on children admitted with bronchiolitis in the post-RSV vaccination era, and understand possible reasons for incomplete vaccine uptake.

Original language	English
Pages (from-to)	120
Journal	Wellcome Open Research
Volume	6
DOIs	https://doi.org/10.12688/wellcomeopenres.16778.4
Publication status	Published - 18 Dec 2024

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Paediatric Emergency Research in the UK and Ireland (PERUKI), Williams, T. C., Cunningham, S., Mpamhanga, C. D., Swann, O. V., Drysdale, S. B., Liu, X., Groves, H., O'Hagan, S., Waterfield, T., Iskander, D., Lyttle, M. D., Marlow, R., Maxwell-Hodkinson, A., Sinha, I., & Roland, D. (2024). Update to: Study Pre-protocol for "BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study". Wellcome Open Research, 6, 120. https://doi.org/10.12688/wellcomeopenres.16778.4

Paediatric Emergency Research in the UK and Ireland (PERUKI) ; Williams, Thomas C ; Cunningham, Steve et al. / Update to : Study Pre-protocol for "BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study". In: Wellcome Open Research. 2024 ; Vol. 6. pp. 120.

@article{635284dabf6d4b1898be95f9e3d819a3,

title = "Update to: Study Pre-protocol for {"}BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study{"}",

abstract = "BACKGROUND: In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation's decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024.STUDY QUESTION: We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV.METHODS AND LIKELY IMPACT: We will conduct a multi-centre study, utilising the PERUKI network used in the original BronchStart study, to assess the effectiveness of maternal vaccination using a test-negative study design. We will gather detailed clinical information on children admitted with bronchiolitis in the post-RSV vaccination era, and understand possible reasons for incomplete vaccine uptake.",

author = "\{Paediatric Emergency Research in the UK and Ireland (PERUKI)\} and Williams, \{Thomas C\} and Steve Cunningham and Mpamhanga, \{Chengetai D\} and Swann, \{Olivia V\} and Drysdale, \{Simon B\} and Xinxue Liu and Helen Groves and Shaun O'Hagan and Thomas Waterfield and Dalia Iskander and Lyttle, \{Mark D\} and Robin Marlow and Abigail Maxwell-Hodkinson and Ian Sinha and Damian Roland",

note = "Copyright: {\textcopyright} 2024 Williams TC et al.",

year = "2024",

month = dec,

day = "18",

doi = "10.12688/wellcomeopenres.16778.4",

language = "English",

volume = "6",

pages = "120",

journal = "Wellcome Open Research",

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publisher = "F1000 Research Ltd",

}

Paediatric Emergency Research in the UK and Ireland (PERUKI), Williams, TC , Cunningham, S, Mpamhanga, CD, Swann, OV, Drysdale, SB, Liu, X, Groves, H, O'Hagan, S, Waterfield, T, Iskander, D, Lyttle, MD, Marlow, R, Maxwell-Hodkinson, A, Sinha, I & Roland, D 2024, 'Update to: Study Pre-protocol for "BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study"', Wellcome Open Research, vol. 6, pp. 120. https://doi.org/10.12688/wellcomeopenres.16778.4

Update to: Study Pre-protocol for "BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study". / Paediatric Emergency Research in the UK and Ireland (PERUKI) ; Williams, Thomas C ; Cunningham, Steve et al.
In: Wellcome Open Research, Vol. 6, 18.12.2024, p. 120.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Update to

T2 - Study Pre-protocol for "BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study"

AU - Paediatric Emergency Research in the UK and Ireland (PERUKI)

AU - Williams, Thomas C

AU - Cunningham, Steve

AU - Mpamhanga, Chengetai D

AU - Swann, Olivia V

AU - Drysdale, Simon B

AU - Liu, Xinxue

AU - Groves, Helen

AU - O'Hagan, Shaun

AU - Waterfield, Thomas

AU - Iskander, Dalia

AU - Lyttle, Mark D

AU - Marlow, Robin

AU - Maxwell-Hodkinson, Abigail

AU - Sinha, Ian

AU - Roland, Damian

PY - 2024/12/18

Y1 - 2024/12/18

N2 - BACKGROUND: In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation's decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024.STUDY QUESTION: We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV.METHODS AND LIKELY IMPACT: We will conduct a multi-centre study, utilising the PERUKI network used in the original BronchStart study, to assess the effectiveness of maternal vaccination using a test-negative study design. We will gather detailed clinical information on children admitted with bronchiolitis in the post-RSV vaccination era, and understand possible reasons for incomplete vaccine uptake.

AB - BACKGROUND: In 2021 we launched the BronchStart study, which collected information on 17,899 presentations in children with serious respiratory tract infections following the release of lockdown restrictions. Our study informed the Joint Committee on Vaccination and Immunisation's decision to recommend the introduction maternal respiratory syncytial virus (RSV) vaccination, which was introduced in the United Kingdom in August/September 2024.STUDY QUESTION: We modified our original protocol to conduct a United Kingdom-wide assessment of maternal vaccination against RSV.METHODS AND LIKELY IMPACT: We will conduct a multi-centre study, utilising the PERUKI network used in the original BronchStart study, to assess the effectiveness of maternal vaccination using a test-negative study design. We will gather detailed clinical information on children admitted with bronchiolitis in the post-RSV vaccination era, and understand possible reasons for incomplete vaccine uptake.

U2 - 10.12688/wellcomeopenres.16778.4

DO - 10.12688/wellcomeopenres.16778.4

M3 - Article

C2 - 34458589

SN - 2398-502X

VL - 6

SP - 120

JO - Wellcome Open Research

JF - Wellcome Open Research

ER -

Paediatric Emergency Research in the UK and Ireland (PERUKI), Williams TC , Cunningham S, Mpamhanga CD, Swann OV, Drysdale SB et al. Update to: Study Pre-protocol for "BronchStart - The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations; a Multi-Centre Prospective Observational Cohort Study". Wellcome Open Research. 2024 Dec 18;6:120. doi: 10.12688/wellcomeopenres.16778.4