Here, we report a real-time, data-driven approach to improve efficiency of an urban dog vaccination campaign. Historically, we vaccinated approximately 35,000 dogs in Blantyre city, Malawi every year over a 20-day period using combined fixed static point (SP) and door-to-door (D2D) approaches. To enhance cost-effectiveness, we used our historical vaccination data set to define the barriers to fixed SP attendance. Guided by these insights, we redesigned our vaccination campaign by increasing the number of fixed SP and eliminating the expensive and labour-intensive D2D component. Combined with roaming SP, whose location was defined through the real time analysis of vaccination coverage data, this novel approach resulted in the vaccination of near identical numbers of dogs in only 11 days. This approach has the potential to act as a template for successful and sustainable future urban SP only dog vaccination campaigns.