Using human induced pluripotent stem cells to treat retinal disease

S. Borooah, M J Phillips, B Bilican, A F Wright, I Wilmut, S Chandran, D Gamm, B Dhillon

Research output: Contribution to journalArticlepeer-review

Abstract

The eye is an ideal target for exploiting the potential of human induced pluripotent stem cell (hiPSC) technology in order to understand disease pathways and explore novel therapeutic strategies for inherited retinal disease. The aim of this article is to map the pathway from state-of-the art laboratory-based discoveries to realising the translational potential of this emerging technique. We describe the relevance and routes to establishing hiPSCs in selected models of human retinal disease. Additionally, we define pathways for applying hiPSC technology in treating currently incurable, progressive and blinding retinal disease.
Original languageEnglish
Pages (from-to)163-181
Number of pages19
JournalProgress in Retinal and Eye Research
Volume37
Early online date6 Oct 2013
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Retina
  • Pluripotent
  • Reprogramming
  • stem cells
  • IPS

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