Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in tsetse in Serengeti, Tanzania

Harriet K Auty, Kim Picozzi, Imna Malele, Steve J Torr, Sarah Cleaveland, Susan Welburn

Research output: Contribution to journalArticlepeer-review

Abstract

Measuring the prevalence of transmissible Trypanosoma brucei rhodesiense in tsetse populations is essential for understanding transmission dynamics, assessing human disease risk and monitoring spatio-temporal trends and the impact of control interventions. Although an important epidemiological variable, identifying flies which carry transmissible infections is difficult, with challenges including low prevalence, presence of other trypanosome species in the same fly, and concurrent detection of immature non-transmissible infections. Diagnostic tests to measure the prevalence of T. b. rhodesiense in tsetse are applied and interpreted inconsistently, and discrepancies between studies suggest this value is not consistently estimated even to within an order of magnitude.
Original languageEnglish
Article numbere1501
Number of pages9
JournalPLoS Neglected Tropical Diseases
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Sensitivity and Specificity
  • Polymerase Chain Reaction
  • Animals
  • Disease Vectors
  • Tanzania
  • Parasitology
  • Trypanosoma brucei rhodesiense
  • Microscopy
  • Trypanosomiasis, African
  • Tsetse Flies
  • Prevalence
  • Models, Theoretical

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