Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology

Research output: Contribution to journalArticlepeer-review

Abstract

The recently described cancer stem cell theory opens up many new challenges and opportunities to identify targets for therapeutic intervention. However, the majority of cancer related therapeutic studies rely upon rodent models of human cancer that rarely translate into clinical success in human patients. Naturally occurring cancers in dogs, cats and humans share biological features, including molecular targets, telomerase biology and tumour genetics. Studying cancer stem cell biology and telomere/telomerase dynamics in the cancer bearing pet population may offer the opportunity to develop a greater understanding of cancer biology in the natural setting and evaluate the development of novel therapies targeted at these systems.
Original languageEnglish
Pages (from-to)380-91
Number of pages12
JournalBBA - Proteins and Proteomics
Volume1792
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • Animals
  • Cat Diseases
  • Cats
  • Disease Models, Animal
  • Dog Diseases
  • Dogs
  • Humans
  • Neoplasms
  • Neoplastic Stem Cells

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