Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology

Lisa Y Pang; David J Argyle

doi:10.1016/j.bbadis.2009.02.010

Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology

Lisa Y Pang, David J Argyle

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

The recently described cancer stem cell theory opens up many new challenges and opportunities to identify targets for therapeutic intervention. However, the majority of cancer related therapeutic studies rely upon rodent models of human cancer that rarely translate into clinical success in human patients. Naturally occurring cancers in dogs, cats and humans share biological features, including molecular targets, telomerase biology and tumour genetics. Studying cancer stem cell biology and telomere/telomerase dynamics in the cancer bearing pet population may offer the opportunity to develop a greater understanding of cancer biology in the natural setting and evaluate the development of novel therapies targeted at these systems.

Original language	English
Pages (from-to)	380-91
Number of pages	12
Journal	BBA - Proteins and Proteomics
Volume	1792
Issue number	4
DOIs	https://doi.org/10.1016/j.bbadis.2009.02.010
Publication status	Published - 2009

Keywords / Materials (for Non-textual outputs)

Animals
Cat Diseases
Cats
Disease Models, Animal
Dog Diseases
Dogs
Humans
Neoplasms
Neoplastic Stem Cells

Access to Document

10.1016/j.bbadis.2009.02.010

Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology
Available under Open Access
Final published version, 704 KB

http://www.sciencedirect.com/science/article/pii/S0925443909000441

Cite this

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title = "Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology",

abstract = "The recently described cancer stem cell theory opens up many new challenges and opportunities to identify targets for therapeutic intervention. However, the majority of cancer related therapeutic studies rely upon rodent models of human cancer that rarely translate into clinical success in human patients. Naturally occurring cancers in dogs, cats and humans share biological features, including molecular targets, telomerase biology and tumour genetics. Studying cancer stem cell biology and telomere/telomerase dynamics in the cancer bearing pet population may offer the opportunity to develop a greater understanding of cancer biology in the natural setting and evaluate the development of novel therapies targeted at these systems.",

keywords = "Animals, Cat Diseases, Cats, Disease Models, Animal, Dog Diseases, Dogs, Humans, Neoplasms, Neoplastic Stem Cells",

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doi = "10.1016/j.bbadis.2009.02.010",

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volume = "1792",

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AU - Argyle, David J

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AB - The recently described cancer stem cell theory opens up many new challenges and opportunities to identify targets for therapeutic intervention. However, the majority of cancer related therapeutic studies rely upon rodent models of human cancer that rarely translate into clinical success in human patients. Naturally occurring cancers in dogs, cats and humans share biological features, including molecular targets, telomerase biology and tumour genetics. Studying cancer stem cell biology and telomere/telomerase dynamics in the cancer bearing pet population may offer the opportunity to develop a greater understanding of cancer biology in the natural setting and evaluate the development of novel therapies targeted at these systems.

KW - Animals

KW - Cat Diseases

KW - Cats

KW - Disease Models, Animal

KW - Dog Diseases

KW - Dogs

KW - Humans

KW - Neoplasms

KW - Neoplastic Stem Cells

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SN - 1570-9639

VL - 1792

SP - 380

EP - 391

JO - BBA - Proteins and Proteomics

JF - BBA - Proteins and Proteomics

IS - 4

ER -

Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology

Abstract

Keywords / Materials (for Non-textual outputs)

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Characterisation of primitive stem cell-like canince cancer cells : identification of therapeutic targets through genomics

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Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology

Abstract

Keywords / Materials (for Non-textual outputs)

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Other files and links

Fingerprint

Projects

Characterisation of primitive stem cell-like canince cancer cells : identification of therapeutic targets through genomics

Cite this