Abstract
The structural manipulation of small molecule metabolites occurs in all organisms and plays a fundamental role in essentially all biological processes. Despite an increasing interest in developing new, non-enzymatic chemical reactions capable of functioning in the presence of living organisms, the ability of such transformations to interface with cellular metabolism and influence biological function is a comparatively underexplored area of research. This review will discuss efforts to combine non-enzymatic chemistry with microbial metabolism. We will highlight recent and historical uses of non-biological reactions to study microbial growth and function, the use of non-enzymatic transformations to rescue auxotrophic microorganisms, and the combination of engineered microbial metabolism and biocompatible chemical reactions for organic synthesis.
Original language | English |
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Pages (from-to) | 71-79 |
Number of pages | 9 |
Journal | Current opinion in chemical biology |
Volume | 25 |
Issue number | 7 |
Early online date | 8 Jan 2015 |
DOIs | |
Publication status | Published - 1 Apr 2015 |
Externally published | Yes |
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Stephen Wallace
- School of Biological Sciences - Personal Chair of Chemical Biotechnology
- Centre for Engineering Biology
Person: Academic: Research Active