Using radiobiology simulators for evaluation of 99mTc Auger electrons for targeted tumor radiotherapy

Adriana Alexandre S. Tavares*, João Manuel R.S. Tavares

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Technetium-99m (99mTc) has been widely used as an imaging agent; however, few studies evaluated its potential use as therapeutic agent. The present study aimed to analyze the potential use of 99mTc Auger electrons for targeted tumor radiotherapy by computational methods. Thus, three different computational simulators were used to estimate the yield of DNA damage, the probability of correct repair and cell kinetic effects after irradiation with 99mTc electrons, iodine-131 beta minus particles and astatine-211 alpha particles. Based on the obtained results, it is possible to conclude that 99mTc CKMMX (all M-shell Coster-Kroning-CK-and super CK transitions) electrons and Auger MXY (all M-shell Auger transitions) are valuable for targeted tumor radiotherapy.

Original languageEnglish
Title of host publicationTechnology and Medical Sciences - TMSi 2010
PublisherCRC Press
Pages311-312
Number of pages2
ISBN (Electronic)9780203816592
ISBN (Print)9781138112896
Publication statusPublished - 11 Jan 2011

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