Using transcriptome profiling to characterize QTL regions on chicken chromosome 5

Guillaume Le Mignon, Colette Désert, Frédérique Pitel, Sophie Leroux, Olivier Demeure, Gregory Guernec, Behnam Abasht, Madeleine Douaire, Pascale Le Roy, Sandrine Lagarrigue

Research output: Contribution to journalArticlepeer-review

Abstract

Although many QTL for various traits have been mapped in livestock, location confidence intervals remain wide that makes difficult the identification of causative mutations. The aim of this study was to test the contribution of microarray data to QTL detection in livestock species. Three different but complementary approaches are proposed to improve characterization of a chicken QTL region for abdominal fatness (AF) previously detected on chromosome 5 (GGA5).
Original languageEnglish
Pages (from-to)575
JournalBMC Genomics
Volume10
DOIs
Publication statusPublished - 2009

Keywords

  • Abdominal Fat
  • Animals
  • Chickens
  • Chromosomes
  • Female
  • Gene Expression Profiling
  • Humans
  • Liver
  • Male
  • Models, Genetic
  • Mutation
  • Oligonucleotide Array Sequence Analysis
  • Quantitative Trait Loci
  • Reproducibility of Results
  • Reverse Transcriptase Polymerase Chain Reaction

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