Projects per year
This work employs two different IM-MS instruments: the commercially available Waters Synapt HDMS instrument, and our Mobility Q-TOF (“MoQTOF”) developed in house. Collision cross-sections obtained from identical molecular species differ to some extent between the two instruments. We observe some good agreement and some variation, with a general trend being that systems examined on the MoQTOF possess and present more compact collision cross-sections than observed with the same species on the Synapt. We attribute these differences principally to slight variations in solution conditions, effecting solution conformations and also to the differences in the source conditions and the ion transmission to the mobility devices affecting gas-phase conformations.
- Ion mobility-mass spectrometry
- Factor H
The MoQToF: Development of an Ion Mobility Mass Spectrometer to Study Structure and Energetics of Proteins and Peptides
28/06/04 → 27/06/07
1/03/03 → 31/07/08