v-Src's hold over actin and cell adhesions

Margaret C Frame; Valerie J Fincham; Neil O Carragher; John A Wyke

doi:10.1038/nrm779

v-Src's hold over actin and cell adhesions

Margaret C Frame, Valerie J Fincham, Neil O Carragher, John A Wyke

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.

Original language	English
Pages (from-to)	233-45
Number of pages	13
Journal	Nature reviews Molecular cell biology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1038/nrm779
Publication status	Published - Apr 2002

Keywords / Materials (for Non-textual outputs)

Actins
Animals
Cadherins
Calpain
Cell Adhesion
Cell Cycle
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Guanine Nucleotide Exchange Factors
Humans
Models, Biological
Nuclear Proteins
Oncogene Protein pp60(v-src)
Protein-Tyrosine Kinases
Proto-Oncogene Proteins pp60(c-src)
Repressor Proteins
Signal Transduction

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title = "v-Src's hold over actin and cell adhesions",

abstract = "The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.",

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author = "Frame, {Margaret C} and Fincham, {Valerie J} and Carragher, {Neil O} and Wyke, {John A}",

year = "2002",

month = apr,

doi = "10.1038/nrm779",

language = "English",

volume = "3",

pages = "233--45",

journal = "Nature reviews Molecular cell biology",

issn = "1471-0072",

publisher = "Nature Publishing Group",

number = "4",

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T1 - v-Src's hold over actin and cell adhesions

AU - Frame, Margaret C

AU - Fincham, Valerie J

AU - Carragher, Neil O

AU - Wyke, John A

PY - 2002/4

Y1 - 2002/4

N2 - The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.

AB - The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.

KW - Actins

KW - Animals

KW - Cadherins

KW - Calpain

KW - Cell Adhesion

KW - Cell Cycle

KW - Focal Adhesion Kinase 1

KW - Focal Adhesion Protein-Tyrosine Kinases

KW - Guanine Nucleotide Exchange Factors

KW - Humans

KW - Models, Biological

KW - Nuclear Proteins

KW - Oncogene Protein pp60(v-src)

KW - Protein-Tyrosine Kinases

KW - Proto-Oncogene Proteins pp60(c-src)

KW - Repressor Proteins

KW - Signal Transduction

U2 - 10.1038/nrm779

DO - 10.1038/nrm779

M3 - Article

C2 - 11994743

SN - 1471-0072

VL - 3

SP - 233

EP - 245

JO - Nature reviews Molecular cell biology

JF - Nature reviews Molecular cell biology

IS - 4

ER -

v-Src's hold over actin and cell adhesions

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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