v-Src's hold over actin and cell adhesions

Margaret C Frame, Valerie J Fincham, Neil O Carragher, John A Wyke

Research output: Contribution to journalArticlepeer-review

Abstract

The oncoprotein v-Src and its cellular homologue (c-Src) are tyrosine kinases that modulate the actin cytoskeleton and cell adhesions. Through the concerted action of their protein-interaction and kinase domains, they are targeted to cell matrix integrin adhesions or cadherin-dependent junctions between epithelial cells, where they phosphorylate substrates that induce adhesion turnover and actin re-modelling. Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src.
Original languageEnglish
Pages (from-to)233-45
Number of pages13
JournalNature reviews Molecular cell biology
Volume3
Issue number4
DOIs
Publication statusPublished - Apr 2002

Keywords

  • Actins
  • Animals
  • Cadherins
  • Calpain
  • Cell Adhesion
  • Cell Cycle
  • Focal Adhesion Kinase 1
  • Focal Adhesion Protein-Tyrosine Kinases
  • Guanine Nucleotide Exchange Factors
  • Humans
  • Models, Biological
  • Nuclear Proteins
  • Oncogene Protein pp60(v-src)
  • Protein-Tyrosine Kinases
  • Proto-Oncogene Proteins pp60(c-src)
  • Repressor Proteins
  • Signal Transduction

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