Validation of the 4AT, a new instrument for rapid delirium screening: A study in 234 hospitalised older people

Giuseppe Bellelli, Alessandro Morandi, Daniel H J Davis, Paolo Mazzola, Renato Turco, Simona Gentile, Tracy Ryan, Helen Cash, Fabio Guerini, Tiziana Torpilliesi, Francesco Del Santo, Marco Trabucchi, Giorgio Annoni, Alasdair M. J. MacLullich

Research output: Contribution to journalArticlepeer-review


Objective: to evaluate the performance of the 4 ‘A’s Test (4AT) in screening for delirium in older patients. The 4AT is a new test for rapid screening of delirium in routine clinical practice.

Design: prospective study of consecutively admitted elderly patients with independent 4AT and reference standard assessments.

Setting: an acute geriatrics ward and a department of rehabilitation.

Participants: two hundred and thirty-six patients (aged ≥70 years) consecutively admitted over a period of 4 months.

Measurements: in each centre, the 4AT was administered by a geriatrician to eligible patients within 24 h of admission. Reference standard delirium diagnosis (DSM-IV-TR criteria) was obtained within 30 min by a different geriatrician who was blind to the 4AT score. The presence of dementia was assessed using the Alzheimer's Questionnaire and the informant section of the Clinical Dementia Rating scale. The main outcome measure was the accuracy of the 4AT in diagnosing delirium.

Results: patients were 83.9 ± 6.1 years old, and the majority were women (64%). Delirium was detected in 12.3% (n = 29), dementia in 31.2% (n = 74) and a combination of both in 7.2% (n = 17). The 4AT had a sensitivity of 89.7% and specificity 84.1% for delirium. The areas under the receiver operating characteristic curves for delirium diagnosis were 0.93 in the whole population, 0.92 in patients without dementia and 0.89 in patients with dementia.

Conclusions: the 4AT is a sensitive and specific method of screening for delirium in hospitalised older people. Its brevity and simplicity support its use in routine clinical practice.
Original languageEnglish
Pages (from-to)496-502
Number of pages7
JournalAge and Ageing
Issue number4
Early online date2 Mar 2014
Publication statusPublished - 31 Jul 2014


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